[Latin Name]Huperzia serratum

[Source] Huperziceae whole herb from China

[Appearance]Brown to white

[Ingredient]Huperzine A

[Specification]Huperzine A 1% – 5%, HPLC

[Solubility] Soluble in chloroform, methanol, ethanol, slightly soluble in water

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[What is Huperzine A]

Huperzia is a type of moss that grows in China. It is related to club mosses (the Lycopodiaceae family) and is known to some botanists as Lycopodium serratum . The whole prepared moss was used traditionally. Modern herbal preparations use only the isolated alkaloid known as huperzine A. Huperzine A is an alkaloid found in huperzia that has been reported to prevent the breakdown of acetylcholine, an important substance needed by the nervous system to transmit information from cell to cell. Animal research has suggested that huperzine A’s ability to preserve acetylcholine may be greater than that of some prescription drugs. Loss of acetylcholine function is a primary feature of several disorders of brain function, including Alzheimer’s disease . Huperzine A may also have a protective effect on brain tissue, further increasing its theoretical potential for helping reduce symptoms of some brain disorders.

[Function] Used in alternative medicine, huperzine A has been found to act as a cholinesterase inhibitor, a type of medicine used to prevent the breakdown of acetylcholine (a chemical essential to learning and memory).

Not only used as a treatment for Alzheimer’s disease, huperzine A is also said to enhance learning and memory and to protect against age-related cognitive decline.

In addition, huperzine A is sometimes used to boost energy, increase alertness, and aid in the treatment of myasthenia gravis (an autoimmune disorder that affects the muscles).

Video abstract of original research paper “In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs” published in the open access journal Clinical, Cosmetic and Investigational Dermatology by McCook et al.

Background: Inhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents. Sodium copper chlorophyllin complex is being used therapeutically as a component in anti-aging cosmeceuticals, and has been shown to have anti-hyaluronidase activity. In this study we evaluated various commercial lots of sodium copper chlorophyllin complex to identify the primary small molecule constituents, and to test various sodium copper chlorophyllin complexes and their small molecule analog compounds for hyaluronidase inhibitory activity in vitro. Ascorbate analogs were tested in combination with copper chlorophyllin complexes for potential additive or synergistic activity.
Materials and methods: For hyaluronidase activity assays, dilutions of test materials were evaluated for hydrolytic activity of hyaluronidase by precipitation of non-digested hyaluronate by measuring related turbidity at 595 nm. High-performance liquid chromatography and mass spectroscopy was used to analyze and identify the primary small molecule constituents in various old and new commercial lots of sodium copper chlorophyllin complex.
Results: The most active small molecule component of sodium copper chlorophyllin complex was disodium copper isochlorin e4, followed by oxidized disodium copper isochlorin e4. Sodium copper chlorophyllin complex and copper isochlorin e4 disodium salt had hyaluronidase inhibitory activity down to 10 μg/mL. The oxidized form of copper isochlorin e4 disodium salt had substantial hyaluronidase inhibitory activity at 100 μg/mL but not at 10 μg/mL. Ascorbate derivatives did not enhance the hyaluronidase inhibitory activity of sodium copper chlorophyllin. Copper isochlorin e4 analogs were always the dominant components of the small molecule content of the commercial lots tested; oxidized copper isochlorin e4 was found in increased concentrations in older compared to newer lots tested.
Conclusion: These results support the concept of using the hyaluronidase inhibitory activity of sodium copper chlorophyllin complex to increase the hyaluronic acid level of the dermal extracellular matrix for the improvement of the appearance of aging facial skin.

View the original paper here: https://www.dovepress.com/in-vitro-inhibition-of-hyaluronidase-by-sodium-copper-chlorophyllin-co-peer-reviewed-article-CCID

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KangaCan™

KangaCan™ , Stevia and how we came to be….

KangaCan is a dream come true for folks like us who take pride in making our own organic products. Just like everyone else we wanted an alternative to sugar and corn syrup. Our problem was a natural alternative was not easy to find. And that is how Kanga Can got started.

We all know there are many artificial alternatives, but even the “natural organic” Stevia sweeteners are commercially produced and often involve a water paste which is then treated by powerful chemical solvents. In the past purifying Stevia crystal’s from leaf and scraps was a messy, tiresome task with hit and miss yields at best. Now with the aid of Kanga Can and dry ice, extracting the crystals off of the Stevia leaves is quick clean work.

Don’t worry! No power tools, water or mess is involved when you use THE WORLDS FIRST manufactured dry ice hopper. KangaCan has perfected the dry ice extraction process for you.

In the past dry ice separation was only available to scientists and botanists. Now thanks to KangaCan, quick clean extraction is in the hands of every do it yourself-er, like you and me! What is even sweeter is dry ice can be bought at many supermarkets.

Simply add dry ice into the KangaCan with crushed dried Stevia, Slide on the pouch, and shake the KangaCan up and down. My dear friend, please trust me when I say, immediately pure Stevia crystals will emerge through the drum like mesh on the end. Shake over a smooth table and scrape up the particulate matter.

Everyone is starting to care what goes inside their bodies. Many are looking for alternative sweeteners. Stevia is one of those alternatives. We had originally experimented with Stevia and found the leaves had a somewhat liquorish taste. We feel that the crystals when separated from the Stevia leaves are stronger and sweeter. We hope you will too.

At KangaCan we want your whole purchasing process to be a pleasant one. From easily learning everything you need to make an informed purchase to receiving your KangaCan quickly. With instructions you can use to get quick results. You will not be disappointed!

KangaCan™ was founded in August 2011. Started in the San Fernando Valley of Los Angeles.
KANGACAN NEITHER MAKES NOR INTENDS TO MAKE CLAIMS THAT KANGACAN PRODUCTS CAN BE USED TO DIAGNOSE, TREAT, CURE, MITIGATE OR PREVENT ANY DISEASE. THESE CLAIMS HAVE NOT BEEN CLINICALLY PROVEN OR EVALUATED BY THE FDA. KANGACAN PRODUCTS ARE NOT DESIGNED TO, AND KANGACAN DOES NOT, PROVIDE MEDICAL ADVICE. ALL CONTENT INCLUDING TEXT, GRAPHICS, IMAGES AND INFORMATION AVAILABLE ARE FOR GENERAL INFORMATIONAL PURPOSES ONLY.
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