[Latin Name] Corynante Yohimbe

[Plant Source] Yohimbe bark collected from Africa

[Specifications] Yohimbine 8% (HPLC)

[Appearance] Red Brown Fine Powder

[Particle size] 80 Mesh

[Loss on drying] 5.0%

[Heavy Metal] 10PPM

[Extract solvents] Ethanol

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Package] Packed in paper-drums and two plastic-bags inside. Net weight:25kgs/drum

[What is yohimbe]

Yohimbe is a tree that grows in Africa, and the natives there have used the crude bark and purified compound to enhance sexual desire and performance. Yohimbe has been used for centuries as an aphrodisiac. It has even been smoked as a hallucinogen. Nowadays, Yohimbe bark extract is mostly used to treat impotence for men and women.

When ingested, Yohimbe is assimilated into the blood stream, and Yohimbe’s energizing effects come from its ability to increase blood flow to the genitals - and this applies to both men and women.Aside from its aphrodisiac effects, new research also show that Yohimbe has powerful antioxidant effects.

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[Function]

Yohimbe Bark Extract Benefits£º

1.It’s an aphrodisiac for both men and women

2.Be used to fight impotence

3.It is shown to be a powerful antioxidant

4.It also helps prevent arteries from getting clogged

5.It helps sexual performance, increase libido

6.Ithas also been shown to help prevent heart attacks

Was ist Kognitionswissenschaft?

Viele Universitäten biete heutzutage Kurse und Studiengänge aus dem Gebiet der Kognitionswissenschaft an. Aber was genau dieses Gebiet ist, können selbst erfahrene Studenten nur mit Mühe beantworten.
Dieser Film, entstanden in einem Studien Projekt von Studenten der Kognitionswissenschaft aus Osnabrück, versucht einen Einblick in die Disziplinen zu geben, aus denen sich die Kognitionswissenschaft zusammensetzt.

Sehen Sie sich den Film auf Lernfunk.de an:

https://video2.virtuos.uni-osnabrueck.de:8080/engage/ui/watch.html?id=d960e3f5-9012-41c3-8bbf-7345825d5e94

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What is Cognitive Science?

Many Universities nowadays offer courses or study programs in the field of “Cognitive Science”. But when asked to summarize what this field actually is, even senior students struggle to answer.
This movie, created by Cognitive Science students from Osnabrück, Germany, tries to give an insight into the different disciplines that make up their subject of study.

Watch this movie on Lernfunk.de:

https://video2.virtuos.uni-osnabrueck.de:8080/engage/ui/watch.html?id=d960e3f5-9012-41c3-8bbf-7345825d5e94

We are especially grateful to all interviewees
Prof. Dr. Achim Stephan
Prof. Dr. Sven Walter
Prof. Dr. Peter König
Prof. Dr. Gordon Pipa
Prof. Dr. Joachim Hertzberg
Prof. Dr. Kai-Uwe Kühnberger
Prof. Dr. Gunther Heidemann
Prof. Dr. Oliver Vornberger
Prof. Dr. Nikola Kompa
Prof. Dr. Peter Bosch
Prof. Dr-Ing. Claus Rollinger

Narrated by Robet L. Muil

Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis. Walter Georgescu et al (2015), PLoS ONE https://dx.doi.org/10.1371/journal.pone.0129438

Traditionally, the kinetics of DNA repair have been estimated using immunocytochemistry by labeling proteins involved in the DNA damage response (DDR) with fluorescent markers in a fixed cell assay. However, detailed knowledge of DDR dynamics across multiple cell generations cannot be obtained using a limited number of fixed cell time-points. Here we report on the dynamics of 53BP1 radiation induced foci (RIF) across multiple cell generations using live cell imaging of non-malignant human mammary epithelial cells (MCF10A) expressing histone H2B-GFP and the DNA repair protein 53BP1-mCherry. Using automatic extraction of RIF imaging features and linear programming techniques, we were able to characterize detailed RIF kinetics for 24 hours before and 24 hours after exposure to low and high doses of ionizing radiation. High-content-analysis at the single cell level over hundreds of cells allows us to quantify precisely the dose dependence of 53BP1 protein production, RIF nuclear localization and RIF movement after exposure to X-ray. Using elastic registration techniques based on the nuclear pattern of individual cells, we could describe the motion of individual RIF precisely within the nucleus. We show that DNA repair occurs in a limited number of large domains, within which multiple small RIFs form, merge and/or resolve with random motion following normal diffusion law. Large foci formation is shown to be mainly happening through the merging of smaller RIF rather than through growth of an individual focus. We estimate repair domain sizes of 7.5 to 11 µm2 with a maximum number of ~15 domains per MCF10A cell. This work also highlights DDR which are specific to doses larger than 1 Gy such as rapid 53BP1 protein increase in the nucleus and foci diffusion rates that are significantly faster than for spontaneous foci movement. We hypothesize that RIF merging reflects a “stressed” DNA repair process that has been taken outside physiological conditions when too many DSB occur at once. High doses of ionizing radiation lead to RIF merging into repair domains which in turn increases DSB proximity and misrepair. Such finding may therefore be critical to explain the supralinear dose dependence for chromosomal rearrangement and cell death measured after exposure to ionizing radiation.