[Specification] 99%

[Appearance] Dark Green powder

Plant Part Used:

[Particle size] 80Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is that?]

Chlorophyll is a natural green pigment which is obtained through extraction and refining processes from natural green plants or silkworm feces.Chlorophyll is stabilized chlorophyll, which is prepared from chlorophyll by saponification and replacement of magnesium atom with copper and sodium. Chlorophyll is dark green to blue black powder, easily soluble in water but slightly soluble in alcohol and chloroform, with transparent jade green water solution without sediment.

[Function]

1.clears up odors of putrefaction effectively.

2.play an important role on cancer prevention.

3.Chlorophyll has superior coloring strength and good stabilization in neutral and alkali solutions.

4.Chlorophyll has effect on liver protection, fastening healing of stomach ulcers and intestine ulcers.

5.The active ingredient in a number of internally-taken preparations intended to reduce odors associated with incontinence, colostomies and similar procedures, as well as body odor in general.

6.Chlorophyll has strong antibacterial action, which makes it useful in surgeries, ulcerative carcinoma, acute rhinitis and rhinosinusitis, chronic ear infections, inflammations, etc.

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Titre du document / Document title
Cytotoxic activity of Justicia spicigera is inhibited by bcl-2 proto-oncogene and induces apoptosis in a cell cycle dependent fashion
Auteur(s) / Author(s)
CACERES-CORTES J. R. (1) ; CANTU-GARZA F. A. (2) ; MENDOZA-MATA M. T. (3) ; CHAVEZ-GONZALEZ M. A. (1) ; RAMOS-MANDUJANO G. (1) ; ZAMBRANO-RAMIREZ I. R. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Research Unit of Cell Differentiation and Cancer, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, MEXIQUE
(2) Chemistry Engineering Department, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, ESPAGNE
(3) Pharmacology Department, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, ESPAGNE

Résumé / Abstract
Identification of compounds from plants is of clinical significance because of the effect that they might have in patients with haematopoietic disorders. We studied the effect of the plant extract Justicia spicigera (Acanthaceae) in different haematopoietic cells: human leukaemic cell lines, umbilical cord blood cells, and mouse bone marrow cells. By examining colony formation and performing the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay it was shown that the plant extract of Justicia spicigera contains cytotoxic factors for leukaemic cells and has no proliferative activity on normal haematopoietic progenitor cells. Our results show that this plant extract induces apoptosis in the human leukaemia cell line TF-1, but not in the bcl-2 transfectant cell line TB-1. Similar results were obtained using a haemopoietic cell line 32D and 32DBcl2. The cultures of umbilical cord blood cells and mouse bone marrow that contain granulocyte-macrophage colony-stimulating factor (GM-CSF) do not proliferate or become terminally differentiated in the presence of the infusion of Justicia spicigera. GM-CSF that acts by abrogating programmed cell death is not sufficient to inhibit the apoptotic stimulus in TF-1 and 32D cells. Moreover mouse fibroblasts (3T3) and two cervical carcinoma cell lines CALO and INBL, undergo apoptosis in the presence of different concentrations of an infusion from the plant. Our data show that there is a strong correlation between the cytotoxic effect and cell proliferation. Together, these results indicate that the plant infusion of Justicia spicigera does not contain any haematopoietic activity, induces apoptosis inhibited by bcl-2 and is linked to cell proliferation.
Revue / Journal Title
PTR. Phytotherapy research ISSN 0951-418X
Source / Source
2001, vol. 15, no8, pp. 691-697 (24 ref.)
Langue / Language
Anglais

Editeur / Publisher
Wiley, Chichester, ROYAUME-UNI (1987) (Revue)

Mots-clés anglais / English Keywords
America ; Central America ; Spermatophyta ; Angiospermae ; Dicotyledones ; Acanthaceae ; Mexico ; Folk medicine ; Pharmacognosy ; Animal ; Human ; Apoptosis ; In vitro ; Cell proliferation ; Antineoplastic agent ; Tumor cell ; Biological activity ; Cytotoxicity ; Plant origin ; Medicinal plant ;