[Latin Name] Griffonia simplicifolia

[Plant Source] Griffonia Seed

[Specifications] 98%; 99% HPLC

[Appearance] White fine powder

Plant Part Used: Seed

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is 5-HTP]

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson’s disease.

 [How does it work?]

5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. Since 5-HTP increases the synthesis of serotonin, it is used for several diseases where serotonin is believed to play an important role including depression, insomnia, obesity, and many other conditions.

[Function]

Depression. Some clinical research shows that taking 5-HTP by mouth improve symptoms of depression in some people. Some clinical research shows that taking 5-HTP by mouth might be as beneficial as certain prescription antidepressant drugs for improving depression symptoms. In most studies, 150-800 mg daily of 5-HTP was taken. In some cases, higher doses have been used.

Down syndrome. Some research shows that giving 5-HTP to infants with Down syndrome might improve muscle and activity. Other research shows that it does not improve muscle or development when taken from infancy until 3-4 years of age. Research also shows that taking 5-HTP along with conventional prescription drugs does improve development, social skills, or language skills.

Anxiety 5-HTP was found to be protective against carbon dioxide-induced panic attacks. One study compared 5-HTP and the prescription medication clomipramine for anxiety. Clomipramine is a tricyclic antidepressant used for treating obsessive-compulsive disorder. 5-HTP was found to be somewhat effective in reducing anxiety symptoms, but not as effective as clomipramine.

Sleep 5-HTP supplements fared a little better for insomnia.5-HTP decreased the time required to get to sleep and decreased the number of nighttime awakenings. Taking 5-HTP along with GABA (gamma-aminobutyric acid), a relaxing neurotransmitter, reduced the time it took to fall asleep and increased the duration and quality of sleep. One study found that children with night terrors benefited from 5-HTP.

UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 16. Introduction to Chemical Biology — Glycobiology & Polyketides — Part 2
View the complete course: https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.

License: Creative Commons BY-NC-SA
Terms of Use: https://ocw.uci.edu/info.
More courses at https://ocw.uci.edu

Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Introduction to Chemical Biology (Chem 128) is part of OpenChem: https://ocw.uci.edu/collections/open_chemistry.html
This video is part of a 18-lecture undergraduate-level course titled “Introduction to Chemical Biology” taught at UC Irvine by Professor Gregory Weiss.

Recorded March 5, 2013.

Index of Topics:
0:00:33 Polysaccharides
0:08:45 Fatty Acid Synthase: Paradigm for a Polyketide Synthesis Machine
0:10:58 Plasma Membrane = Lipid Barrier
0:13:44 Hydrolysis of LIpids in Cell Signaling
0:15:26 Prostaglandin Signaling to Coordinate Cell Response
0:16:15 Leukotrienes Mediate Inflammatory Response
0:19:09 Shutting Down the Prostaglandin Pathway at its Start
0:23:39 Converting Fats into Soaps
0:25:54 Diversifying Products from Polyketide Synthases
0:39:54 Fatty Acid Synthase (FAS) Has a Circular Assembly Line
0:44:18 Terpenes: Built from Isoprene (5C) Units
0:56:18 Inhibition of Cholesterol Synthesis
0:57:48 Cyclization of Straight-Chain Precursors by Enzymes

Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (https://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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