[Latin Name] Allium sativum L.

[Plant Source] from China

[Appearance] Off-white to light yellow  Powder

Plant Part Used:Fruit

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

Main function:

1.Wide-spectrum antibiotic, bacteriostasis and sterilization.

2.Clearing away heat and toxic material, activating blood and dissolving stasis.

3.Lowering blood pressure and blood-fat

4.Protecting brain cell.Resisting tumor

5.Enhancing human immunity and delaying aging.

Applications:

1. Applied in pharmaceutical field, it is mainly used in treating eumycete and bacterial infection, gastroenteritis and Cardiovascular Disease.

2. Applied in health product field, it is usually made into capsule to lower blood pressure and blood-fat and delay senility.

3. Applied in food field, it is mainly used for natural flavour enhancer and widely used in biscuit, bread, meat products and etc.

4. Applied in feed additive field, it is mainly used in feed additive for developing the poultry, livestock and fishes against the disease and promoting growning and improving the flavor of egg and meat.

5. Applied in veterinary field, it is mainly used to inhibit the reproduction of colon bacillus, salmonella and etc. It also can treat respiratory infection and disease of digestive tract of poultry and livestock.

Title: Cyanidin-3-O-glucoside ameliorates lipid and glucose accumulation in C57BL/6J mice via activation of PPAR-α and AMPK?
3rdInternational Conference and Exhibition on Nutrition & Food Sciences
September 23-25, 2014 Valencia , Spain

OMICS International: https://conferenceseries.com/
Pharmaceutical Conferences: https://pharmaceuticalconferences.com
Global OMICS open access Journals: https://omicsonline.org
Global Medical Conferences: https://conferenceseries.com
Global Cancer Conferences: https://cancersummit.org
Global Diabetes Conferences: https://diabetesexpo.com
Global Dental Conferences: https://dentalcongress.com
Global Nursing Conferences: https://nursingconference.com

Abstract
Cyanidin-3-O-glucoside (C3G) is an anthocyanidin abundant in fruits and vegetables that exhibits potent activities in energy metabolism; however, molecular target(s) and the mode of actions of C3G have been elusive. Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses revealed that C3G directly interacted with PPARα ligand-binding domain, thus the C3G induced hepatic fatty acid oxidation and ketogenesis regulating PPARα responsive genes. C3G also bound directly to the α1 subunit of AMPK in cell-free kinase assay, phosphorylated ACC1, decreased hepatic malonyl- CoA concentration, thus reduced hepatic fatty acid synthesis. In high-fat-diet fed C57BL/6J mice orally administrated with C3G for 8 weeks, hepatic and plasma triglycerides were significantly reduced due to the combined effects of PPARα and AMPK activation. Insulin resistance and glucose tolerance were significantly improved with reduction in hepatic gluconeogenesis in C3G mice compared with those of controls. The AMPK activation by C3G led to the phosphorylation inhibition of FoxO1 and CREB to suppress the expressions of key genes in hepatic gluconeogenesis. Body fat accumulation was reduced in C3G fed mice with induction of thermogenic gene expressions in brown adipocytes and energy expenditure was significantly increased in mice fed C3G. Hepatic autophagy pathway was significantly activated in C3G livers, via activation AMPK-mTORsignaling axis and PPARα activation. Autophagy activation may contribute to lowering lipid accumulation in the liver. Collectively, these demonstrate that C3G in diet has profound metabolic roles in regulating lipid metabolism and insulin resistance via activation of both PPARα and AMPK.

Biography

YaoyaoJia earned her Degree of Doctor of Philosophy from Food Science and Technology Department of Biotechnology Graduate School of Korea University. Her research is mainly focus on effects of natural compounds in cellular lipid metabolism and regulation of PPAR activity.

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