[Latin Name] Griffonia simplicifolia

[Plant Source] Griffonia Seed

[Specifications] 98%; 99% HPLC

[Appearance] White fine powder

Plant Part Used: Seed

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is 5-HTP]

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson’s disease.

 [How does it work?]

5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. Since 5-HTP increases the synthesis of serotonin, it is used for several diseases where serotonin is believed to play an important role including depression, insomnia, obesity, and many other conditions.

[Function]

Depression. Some clinical research shows that taking 5-HTP by mouth improve symptoms of depression in some people. Some clinical research shows that taking 5-HTP by mouth might be as beneficial as certain prescription antidepressant drugs for improving depression symptoms. In most studies, 150-800 mg daily of 5-HTP was taken. In some cases, higher doses have been used.

Down syndrome. Some research shows that giving 5-HTP to infants with Down syndrome might improve muscle and activity. Other research shows that it does not improve muscle or development when taken from infancy until 3-4 years of age. Research also shows that taking 5-HTP along with conventional prescription drugs does improve development, social skills, or language skills.

Anxiety 5-HTP was found to be protective against carbon dioxide-induced panic attacks. One study compared 5-HTP and the prescription medication clomipramine for anxiety. Clomipramine is a tricyclic antidepressant used for treating obsessive-compulsive disorder. 5-HTP was found to be somewhat effective in reducing anxiety symptoms, but not as effective as clomipramine.

Sleep 5-HTP supplements fared a little better for insomnia.5-HTP decreased the time required to get to sleep and decreased the number of nighttime awakenings. Taking 5-HTP along with GABA (gamma-aminobutyric acid), a relaxing neurotransmitter, reduced the time it took to fall asleep and increased the duration and quality of sleep. One study found that children with night terrors benefited from 5-HTP.

Horny goat weed, also known as barrenwort, but properly known as, Epimedium grandiflorum, is a popular herbal supplement to improve your libido, but should you actually be taking it? Find out here!

Scientific Literature:

Kim, D. H., Jung, H. A., Sohn, H. S., Kim, J. W., & Choi, J. S. (2017). Potential of icariin metabolites from Epimedium koreanum Nakai as antidiabetic therapeutic agents. Molecules, 22(6), E986. – https://www.ncbi.nlm.nih.gov/pubmed/28608833

Lee, J. K. C., Tan, R. B. W., & Chung, E. (2017). Erectile dysfunction treatment and traditional medicine—can East and West medicine coexist? Translational Andrology and Urology, 6(1), 91–100. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313309/pdf/tau-06-01-091.pdf

Ma, H., He, X., Yang, Y., Li, M., Hao, D., & Jia, Z. (2011). The genus Epimedium: An ethnopharmacological and phytochemical review. Journal of Ethnopharmacology, 134(4), 519-541. – https://www.ncbi.nlm.nih.gov/pubmed/21215308

Qureshi, M., Mehjabeen, Noorjahan, Muhammad, S., Siddiqui, F. A., Baig, I., & Ahmad, M. (2017). Phytochemical and biological assessments on Lipidium meyenii (maca) and Epimidium sagittatum (horny goat weed). Pakistani Journal of Pharmaceutical Sciences, 30(1), 29-36. – https://www.ncbi.nlm.nih.gov/pubmed/28603109

Tan, H. L., Chan, K. G., Pusparajah, P., Saokaew, S., Duangjai, A., Lee, L. H., & Goh, B. H. (2016). Anti-cancer properties of the naturally occurring aphrodisiacs: Icariin and Its derivatives. Frontiers in Pharmacology, 7, 191. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925704/pdf/fphar-07-00191.pdf

Telang, N. T., Li, G., Katdare, M., Sepkovic, D. W., Bradlow, H. L., & Wong, G. Y. C. (2017). The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer. Oncology Letters, 13(4), 2477–2482. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403390/pdf/ol-13-04-2477.pdf

Wang Y., Wang, Y. S., Song, S. L., Liang, H., & Ji, A. G. (2016). Icariin inhibits atherosclerosis progress in Apoe null mice by downregulating CX3CR1 in macrophage. Biochemical and Biophysical Research Communications, 470(4), 845-850. https://www.ncbi.nlm.nih.gov/pubmed/26802470

Wu, L., Du, Z. R., Xu, A. L., Yan, Z., Xiao, H. H., Wong, M. S., Yao, X. S., Chen, W. F. (2017). Neuroprotective effects of total flavonoid fraction of the Epimedium koreanum Nakai extract on dopaminergic neurons: In vivo and in vitro. Biomedical Pharmacotherapy, 91, 651-663. – https://www.ncbi.nlm.nih.gov/pubmed/28494419

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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 16. Introduction to Chemical Biology — Glycobiology & Polyketides — Part 2
View the complete course: https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.

License: Creative Commons BY-NC-SA
Terms of Use: https://ocw.uci.edu/info.
More courses at https://ocw.uci.edu

Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Introduction to Chemical Biology (Chem 128) is part of OpenChem: https://ocw.uci.edu/collections/open_chemistry.html
This video is part of a 18-lecture undergraduate-level course titled “Introduction to Chemical Biology” taught at UC Irvine by Professor Gregory Weiss.

Recorded March 5, 2013.

Index of Topics:
0:00:33 Polysaccharides
0:08:45 Fatty Acid Synthase: Paradigm for a Polyketide Synthesis Machine
0:10:58 Plasma Membrane = Lipid Barrier
0:13:44 Hydrolysis of LIpids in Cell Signaling
0:15:26 Prostaglandin Signaling to Coordinate Cell Response
0:16:15 Leukotrienes Mediate Inflammatory Response
0:19:09 Shutting Down the Prostaglandin Pathway at its Start
0:23:39 Converting Fats into Soaps
0:25:54 Diversifying Products from Polyketide Synthases
0:39:54 Fatty Acid Synthase (FAS) Has a Circular Assembly Line
0:44:18 Terpenes: Built from Isoprene (5C) Units
0:56:18 Inhibition of Cholesterol Synthesis
0:57:48 Cyclization of Straight-Chain Precursors by Enzymes

Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (https://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).