[Latin Name] Griffonia simplicifolia

[Plant Source] Griffonia Seed

[Specifications] 98%; 99% HPLC

[Appearance] White fine powder

Plant Part Used: Seed

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is 5-HTP]

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson’s disease.

 [How does it work?]

5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. Since 5-HTP increases the synthesis of serotonin, it is used for several diseases where serotonin is believed to play an important role including depression, insomnia, obesity, and many other conditions.

[Function]

Depression. Some clinical research shows that taking 5-HTP by mouth improve symptoms of depression in some people. Some clinical research shows that taking 5-HTP by mouth might be as beneficial as certain prescription antidepressant drugs for improving depression symptoms. In most studies, 150-800 mg daily of 5-HTP was taken. In some cases, higher doses have been used.

Down syndrome. Some research shows that giving 5-HTP to infants with Down syndrome might improve muscle and activity. Other research shows that it does not improve muscle or development when taken from infancy until 3-4 years of age. Research also shows that taking 5-HTP along with conventional prescription drugs does improve development, social skills, or language skills.

Anxiety 5-HTP was found to be protective against carbon dioxide-induced panic attacks. One study compared 5-HTP and the prescription medication clomipramine for anxiety. Clomipramine is a tricyclic antidepressant used for treating obsessive-compulsive disorder. 5-HTP was found to be somewhat effective in reducing anxiety symptoms, but not as effective as clomipramine.

Sleep 5-HTP supplements fared a little better for insomnia.5-HTP decreased the time required to get to sleep and decreased the number of nighttime awakenings. Taking 5-HTP along with GABA (gamma-aminobutyric acid), a relaxing neurotransmitter, reduced the time it took to fall asleep and increased the duration and quality of sleep. One study found that children with night terrors benefited from 5-HTP.

https://www.anti-aging-now.com/grapeseed-extract.html -Grape seeds have a high concentration of flavonoids and oligomeric proanthocyanidins, (OPC). These compounds also found in grape seed in lower concentrations in grape skin, and . Grape seed contains various lipids, including the omega-6 fatty acid linoleic acid and the omega-9 fatty acid oleic acid. Grape seed provides the essential amino acids leucine, phenylalanine and valine, and the non-essential amino acids arginine and cystine.

OPCs are found in grape juice and wine. OPC is why we have what is called the French Paradox in that people in France who drink a lot of red wine don’t tend to have a lot of heart problems. Even though they smoke and eat a lot of fatty foods.

(See https://nanohour.beckman.illinois.edu/Nanohour/Nanohour.html)

” A Tooth Problem: Biomodification of Dentin Matrices as Novel Strategy for Dental Therapies”

Prof. Ana Bedran-Russo (UIC College of Dentistry)

“It is estimated that in the United States, 350 million dental restorations
(fillings) are placed every year in dental offices. Sixty percent of those restorations
replace existing failed restorative treatments. The primary reason for failure of
dental restorations is secondary caries (decay), indicative of increased permeability
and debonding between tooth and restorative biomaterial. Current dental adhesive
restorative systems rely on the micromechanical retentions of restorations by
infiltrations of hydrophilic and hydrophobic resins into a collagen-rich surface on
dentin. Our laboratory at UIC has focused on understanding the tooth
biochemistry/biomechanics and explored biomimetic approaches for innovative
restorative/regenerative therapies. Specifically the interactions of olygomeric
proanthocyanidins agents (OPC) with dentin matrices to improve mechanical
properties and reduced biodegradation rates. This presentation will provide (1)
overview of challenges in the harsh oral environment (2) limitations of current
dental therapies and (3) mechanisms of interactions of OPC with type I collagen,
proteoglycans and matrix metalloproteinases (MMPs).”