Special Design for Resveratrol Manufacturer in Moscow
[Latin Name] Polygonum Cuspidatum Sieb. et Zucc [Plant Source] China [Specifications] Resveratrol 50%, 95%, 98% by HPLC [Appearance]Brown or white fine powder [Plant Part Used] Rhizome&Root [Particle size] 80 Mesh [Loss on drying] ≤5.0% [Heavy Metal] ≤10PPM [Storage] Store in cool & dry area, keep away from the direct light and heat. [Package] Packed in paper-drums and two plastic-bags inside. [General feature] 1.100% natural source. Our resveratrol is 100% extracted from natural her...
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[Latin Name] Polygonum Cuspidatum Sieb. et Zucc
[Plant Source] China
[Specifications] Resveratrol 50%, 95%, 98% by HPLC
[Appearance]Brown or white fine powder
[Plant Part Used] Rhizome&Root
[Particle size] 80 Mesh
[Loss on drying] ≤5.0%
[Heavy Metal] ≤10PPM
[Storage] Store in cool & dry area, keep away from the direct light and heat.
[Package] Packed in paper-drums and two plastic-bags inside.
1.100% natural source. Our resveratrol is 100% extracted from natural herb, very safe and more bioactive, which is rich with both CIS-resveratrol and trans-resveratrol.
2.Our resveratrol almost have no unpleasant taste compare to other resveratrols and it can be easier to take by oral.
3.We offer resveratrol at a very competitive price with superb quality.
4.We have a very large output and could manufacturer as customer particular requirement.
Resveratrol is an active component extracted from Huzhang (Polygonum cuspidatum) in China.
It is an antioxidant phenol and a potent vasodilator that inhibits serum triglyceride synthesis, lipid peroxidation, and platelet aggregation.
It is extensively used for treatment of blood vessel disease such as atherosclerosis and hyperlipidemia. In addition, it has anti-virus and anti inflammatory activity, can treat acute microbial infections and viral hepatitis.
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Video abstract of original research paper “In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs” published in the open access journal Clinical, Cosmetic and Investigational Dermatology by McCook et al.
Background: Inhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents. Sodium copper chlorophyllin complex is being used therapeutically as a component in anti-aging cosmeceuticals, and has been shown to have anti-hyaluronidase activity. In this study we evaluated various commercial lots of sodium copper chlorophyllin complex to identify the primary small molecule constituents, and to test various sodium copper chlorophyllin complexes and their small molecule analog compounds for hyaluronidase inhibitory activity in vitro. Ascorbate analogs were tested in combination with copper chlorophyllin complexes for potential additive or synergistic activity.
Materials and methods: For hyaluronidase activity assays, dilutions of test materials were evaluated for hydrolytic activity of hyaluronidase by precipitation of non-digested hyaluronate by measuring related turbidity at 595 nm. High-performance liquid chromatography and mass spectroscopy was used to analyze and identify the primary small molecule constituents in various old and new commercial lots of sodium copper chlorophyllin complex.
Results: The most active small molecule component of sodium copper chlorophyllin complex was disodium copper isochlorin e4, followed by oxidized disodium copper isochlorin e4. Sodium copper chlorophyllin complex and copper isochlorin e4 disodium salt had hyaluronidase inhibitory activity down to 10 μg/mL. The oxidized form of copper isochlorin e4 disodium salt had substantial hyaluronidase inhibitory activity at 100 μg/mL but not at 10 μg/mL. Ascorbate derivatives did not enhance the hyaluronidase inhibitory activity of sodium copper chlorophyllin. Copper isochlorin e4 analogs were always the dominant components of the small molecule content of the commercial lots tested; oxidized copper isochlorin e4 was found in increased concentrations in older compared to newer lots tested.
Conclusion: These results support the concept of using the hyaluronidase inhibitory activity of sodium copper chlorophyllin complex to increase the hyaluronic acid level of the dermal extracellular matrix for the improvement of the appearance of aging facial skin.
View the original paper here: https://www.dovepress.com/in-vitro-inhibition-of-hyaluronidase-by-sodium-copper-chlorophyllin-co-peer-reviewed-article-CCID