Men with ED have a significantly increased risk of having stroke and there is a high prevalence of ED in men with coronary artery disease. Penile artery is one of the smallest and among the first arteries to be affected by atherosclerosis. A man with ED is very likely a cardiac or vascular patient. The INSPIRE – ‘Core Wellness’ program is a focused intervention which reverses Coronary artery disease, thereby improving the cardiovascular fitness, and significantly reducing the risk of ED.