Pycnogenol has a International Popularity beacause it has 77 published clinical studies, 230 scientific medical journals, more than 7000 people the subject of clinical trials, patented in US, proven, safe & efficacious. It is 10 times more powerful than grapeseed, 40 times more powerful than Vitamin E and 350 times more powerful than Vitamin C. If your product has no strong basis and clinical studies, you cannot succeed in the market place. Pycnogenol represents a natural blend of genetically programmed constant proportions of bioflavonoids including catechin, epicatechin, taxifolin, monomers, dimers of catechin and epicatechin, oligomeric procyanidnins and phenolic fruit acids such as ferulic acid and caffeic acid.