Grape seed extract, which is made from the seeds of wine grapes, is promoted as a dietary supplement for various conditions, including venous insufficiency (when veins have problems sending blood from the legs back to the heart), promoting wound healing, and reducing inflammation.

Grape seed extract contains proanthocyanidins, which have been studied for a variety of health conditions.

Since ancient Greece, various parts of the grape have been used for medicinal purposes. There are reports of ancient Egyptians and Europeans have used grapes and grapes seeds as well.

Today, we know that grape seed extract contains oligomeric proanthocyanidin (OPC) an antioxidant that is believed to improve certain health conditions. Some scientific evidence supports the use of of grape seed or grape seed extract to reduce poor blood flow in the legs and to reduce eye stress due to glare.