[Latin Name] Curcuma longa L.

[Plant Source] Root From India

[Specification] Curcuminoids 95% HPLC

[Appearance] Yellow powder

Plant Part Used: Root

[Particle size]80Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is Curcuma Longa?]

Turmeric is an herbaceous plant known scientifically as Curcuma longa. It belongs to the Zingiberaceae family, which includes ginger. Tumeric has rhizomes rather than true roots, which are the primary source of commercial value for this plant. Tumeric originates from southwest India, where it has been a stable of Siddha medicine for thousands of years. It is also a common spice in Indian cuisine and is often used as flavoring for Asian mustards.

Ph.D. mentor: Prof. Ravi S. Kane, P. K. Lashmet Professor and Dept. Head of Chemical and Biochemical Engineering at RPI
Ph.D. committee members: Prof. Peter M. Tessier, RPI CHBE; Prof. Steven M. Cramer, RPI CHBE; Prof. Shekhar Garde, RPI CHBE and Dean of Engineering; Prof. Marlene Belfort, SUNY Albany Biological Sciences

Dissertation Title: The design of multivalent conjugates for anthrax toxin, influenza, and HIV inhibition

When proteins, peptides, oligonucleotides, or polysaccharides are strategically arranged on biocompatible scaffolds, the activity of such molecules can be profoundly affected. Creating multivalent arrangements, which involve the simultaneous interaction of multiple binding elements with multiple target receptors, can be a powerful method for enhancing the efficacy of bioactive molecules. For example, one can synthesize multivalent ligands that enhance receptor binding affinities by several orders of magnitude over the corresponding monovalent receptor-ligand interaction. In this talk, I will describe my research on various structure-based designs of multivalent macromolecular conjugates for the effective inhibition of three different pathogens with broad public interest: anthrax, HIV, and influenza. Identifying conserved targets in the pathogenic progression of each of these is a key aspect of this research, and once appropriate targets have been identified, using strategically-designed scaffolds to control the multivalent arrangements of targeting ligands is crucial. Indeed, achieving precise control over the display of biologically relevant ligands may be the key to understanding mechanisms driving a diverse set of biological processes ranging from the inhibition of pathogenicity to effecting stem cell differentiation. Therefore, the study of multivalent complexes such as these has the potential to lead to very promising therapeutic applications.

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