[Latin Name] Griffonia simplicifolia

[Plant Source] Griffonia Seed

[Specifications] 98%; 99% HPLC

[Appearance] White fine powder

Plant Part Used: Seed

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is 5-HTP]

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson’s disease.

 [How does it work?]

5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. Since 5-HTP increases the synthesis of serotonin, it is used for several diseases where serotonin is believed to play an important role including depression, insomnia, obesity, and many other conditions.

[Function]

Depression. Some clinical research shows that taking 5-HTP by mouth improve symptoms of depression in some people. Some clinical research shows that taking 5-HTP by mouth might be as beneficial as certain prescription antidepressant drugs for improving depression symptoms. In most studies, 150-800 mg daily of 5-HTP was taken. In some cases, higher doses have been used.

Down syndrome. Some research shows that giving 5-HTP to infants with Down syndrome might improve muscle and activity. Other research shows that it does not improve muscle or development when taken from infancy until 3-4 years of age. Research also shows that taking 5-HTP along with conventional prescription drugs does improve development, social skills, or language skills.

Anxiety 5-HTP was found to be protective against carbon dioxide-induced panic attacks. One study compared 5-HTP and the prescription medication clomipramine for anxiety. Clomipramine is a tricyclic antidepressant used for treating obsessive-compulsive disorder. 5-HTP was found to be somewhat effective in reducing anxiety symptoms, but not as effective as clomipramine.

Sleep 5-HTP supplements fared a little better for insomnia.5-HTP decreased the time required to get to sleep and decreased the number of nighttime awakenings. Taking 5-HTP along with GABA (gamma-aminobutyric acid), a relaxing neurotransmitter, reduced the time it took to fall asleep and increased the duration and quality of sleep. One study found that children with night terrors benefited from 5-HTP.

Teeneke walks us through the process of creating a quick botanical extract using vegetable glycerin.

Found an amazing vid that shows every bit of happenings inside a cell with bright and vivid graphic presentation.

Notes:
Cell – the smallest unit of life. It takes up useful molecules and gets rid of waste molecules. It breaks down larger molecules to produce usable energy in the form of ATP molecules, where energy was stored, to synthesize other larger molecules. Big molecules are CONSTANTLY being breaking down into small molecules and the pieces used to make big molecules again, a process called ‘turnover’.

Selectin – any of a family of sugar-binding lectins that are found on the surface of cells (as endothelial cells and white blood cells) and that promote their adhesion to other cells and mediate their migration to sites of inflammation.

Leukocytes – white blood cell

Chemokine – any of a group of chemotactic cytokines that are produced by various cells (as at sites of inflammation), that are thought to provide directional cues for the movement of white blood cells (as T cells, monocytes, and neutrophils), and that include some playing a role in HIV infection because the cell surface receptors to which they bind are also used by specific strains of HIV for entry into cells.

Proteoglycan – any of a class of glycoproteins of high molecular weight that are found in the extracellular matrix of connective tissue, are made up mostly of carbohydrate consisting of various polysaccharide side chains linked to a protein, and resemble polysaccharides rather than proteins in their properties.

2 classes of receptors –
Ligand-gated ion channel
G protein-coupled receptor

Mitochondria – an organelle which break down nutrients such as glucose and provide the cell with energy to perform its function.

Membrane – defines the boundary of the cell and consists of a double layer of fatlike lipid molecules. Embedded in the membrane are a variety of protein molecules that have special functions.

Microtubule – a long strand of bundles of protein filaments arranged around a hollow core; part of the cytoskeleton and involved in transporting substances from place to place within a cell.

G-protein – a protein coupled to a metabotropic receptor. When a molecule of the neurotransmitter binds with the receptor, the receptor activates a G protein situated inside the membrane next to the receptor.

Cited:
Almon, Richard. Drugs, Stress, and Human Function. Cognella, Inc., 2013. USA

Carlson, Neil R., Foundations of Behavioral Neuroscience, 9th ed. Pearson, 2014. USA

U.S. National Library of Medicine, MedLine Plus, https://www.nlm.nih.gov/medlineplus/

(I do not own this video)