[Latin Name] Griffonia simplicifolia

[Plant Source] Griffonia Seed

[Specifications] 98%; 99% HPLC

[Appearance] White fine powder

Plant Part Used: Seed

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is 5-HTP]

5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson’s disease.

 [How does it work?]

5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. Since 5-HTP increases the synthesis of serotonin, it is used for several diseases where serotonin is believed to play an important role including depression, insomnia, obesity, and many other conditions.

[Function]

Depression. Some clinical research shows that taking 5-HTP by mouth improve symptoms of depression in some people. Some clinical research shows that taking 5-HTP by mouth might be as beneficial as certain prescription antidepressant drugs for improving depression symptoms. In most studies, 150-800 mg daily of 5-HTP was taken. In some cases, higher doses have been used.

Down syndrome. Some research shows that giving 5-HTP to infants with Down syndrome might improve muscle and activity. Other research shows that it does not improve muscle or development when taken from infancy until 3-4 years of age. Research also shows that taking 5-HTP along with conventional prescription drugs does improve development, social skills, or language skills.

Anxiety 5-HTP was found to be protective against carbon dioxide-induced panic attacks. One study compared 5-HTP and the prescription medication clomipramine for anxiety. Clomipramine is a tricyclic antidepressant used for treating obsessive-compulsive disorder. 5-HTP was found to be somewhat effective in reducing anxiety symptoms, but not as effective as clomipramine.

Sleep 5-HTP supplements fared a little better for insomnia.5-HTP decreased the time required to get to sleep and decreased the number of nighttime awakenings. Taking 5-HTP along with GABA (gamma-aminobutyric acid), a relaxing neurotransmitter, reduced the time it took to fall asleep and increased the duration and quality of sleep. One study found that children with night terrors benefited from 5-HTP.

Heres the list people….
Methadone-oral 80-90%, halflife- 24-36 hours, rectal 76%
Ketobemiodone oral was 34% +/-10%, rectally 44% +/- 9%, half-life is 2.25- 2.45 hours
Meperidine rectal bioavailability is approximately 55%, 80% to 85% IM, elimination half-life 3.0 h
Buprenorphine highly protein bound 96%, sublingual bioavailability is approximately 30%, oral is 15-22%, 90-100% IM, elimination half-life is 12-44 hours
Hydromorphone– 5-8 times as potent as morphine, intranasal- 52.4%, Rectal administration 33% ,Oral-30-35%, (also reported as 50.7% +/- 29.8% oral; 33% +/- 22% rectal; 54.4% – 59.8% nasal)
Dihydrocodeine oral-20-21% halflife 4 hours
Heroin oral ~35% IV- 100% IM-85% Smoked (or vaporized?) 52-55% vaporized Semisynthetic derivative, Intranasal 44-61%
Fentanyl- Bioavailability 92% (transdermal), 50% (sublingual/ buccal (against cheek), Protein binding 80-85%, half-life 3-12 hours
Sufentanil intranasal bio- 78%,
Remifentanil Protein binding 70% (bound to plasma proteins) Half life 1-20 minutes
Alfentanil- IV ~100%, 92% protein binding, half life is 1.5-2 hours
Morphine ~32% oral/rectal, insuffulated- 15-20%, Chitosan(a linear polysaccharide that helps absorb drugs better) has been shown to increase nasal bioavailability of morphine from around 10-20% to over 60%, SC-60%, protein binding 30-40%, half-life is 2-3 hours
Oxycodone-oral 60-87% intranasal- widely varies 45-70%
Hydrocodone- oral bioavailability is not really known but it is around oxycodone bioavailability, ~70% of it is usually absorbed, half-life is 4-8 hours
Oxymorphone nasal bioavailabilty [43%] orals low 10-20%
Butorphanol -oral 5-17% due to high first pass metabolism
Tramadol- the absolute bioavailability of rectally admistered tramadol in the suppositories was 77.0%, Oral-68-72% (Increases with repeated dosing) Half life 5-7 hours
Codeine- following rectal or oral administration with a systemic availability of about 90%; in one study clearance varied 4-fold and systemic availability after oral dosage was between 50 and 84%
Diphenoxylate Protein binding 74-95% Half life 12-14 hours used for diarrhea, (does not appreciably cross the blood-brain barrier)
Pethidine(meperidine) Absorption Oral bioavailability is 50-60% in patients with normal hepatic function. IM 80-85%, Protein Binding 65-75%, Half Life 3-5 hours
Normeperidine is about half as potent as meperidine, but it has twice the CNS stimulation effects.
Pentazocine- Bioavailability ~20% orally, Half-life 2 to 3 hours

Opiate Antagonists
Naloxone oral- 2-4% (90% absorption but high first-pass metabolism), Half life 1-1.5 hours
Naltrexone Oral Bioavailability 5-40%, Protein binding 21%, Half life-4 hours (naltrexone),
and 13 hours (6-β-naltrexol) (metabolite)

This short definition of stevia presentes its attributes and benefits. Safe for children (the product and the video); safe for adults. WARNING: the FDA, FBI, CIA, ACLU, AFL CIO have not evaluated these statements, nor are these statements intended to remedy or cure anything. Certainly not global warming though, perhaps, bovine flatulence.