[Products Name]  Royal jelly powder，Lyophilized royal jelly powder

[Specification]  10-HDA 4.0%, 5.0%, 6.0%, HPLC

[Gerneral feature]

1. Low antibiotics, Chloramphenicol< 0.1ppb

2. certified by, according to EOS & NOP standard;

3.100% pure with no additives;

4. More easily absorbed into the body than fresh royal jelly

5. Can be easily produced into tablets.

[Our advantages]

1. 600 bee farmers, 150 units of bee-feeding groups located in natural mountains;
2. certificated by;
3. NON-antibiotics, widely exported to Europe;
4. Health Certificate, Sanitary Certificate and Quality Certificate are available.

[Lyophilized technology]

Lyophilized technology, also known as Freeze-drying, it is a dehydration process typically used to maintain activity of all nutrition ingredients in royal jelly, also to make the royal jelly convenient for transport. Freeze-drying works by freezing the material and then reducing the surrounding pressure to allow the frozen water in the material to sublimate directly from the solid phase to the gas phase. This technology can maintain all activity of nutrition ingredient.

Lyophilized royal jelly powder is processed directly from fresh royal jelly.

3kgs fresh royal jelly is used to make 1kg lyophilized royal jelly powder.

During all the production process, there is no additives.

[Packing]

5kg/bag, 25kgs/drum

1kg/bag, 20kgs/carton

Main indices of physical and chemic in Lyophilized royal jelly

[Our work flow]

Our Lyophilized Royal Jelly Powder is produced in this way: we lyophilize the fresh royal jelly by advanced freeze-drying facilities without losing any nutritional ingredients, reserving the natural ingredients in utmost, and then make them into the form of powder, for any food additives are not needed to add.

The raw material we use is the natural fresh royal jelly which is up to the export standard . We process our products strictly according to export standard. Our workshop is up to the requirements of GMP.

Royal Jelly powder has been selected as drug excipients by many European and American pharmaceutical producing enterprises.Meanwhile it is applies to health food and cosmetics industries.

[Quality control]

Traceability record

GMP standard production

Advanced inspection equipment

[Function]

1.Enhances the immune system

2.Promotes wound healing

3.Has antitumor/anticancer properties

4.Lowers cholesterol levels

5.Increases fat metabolism

6.Is a powerful antioxidant

7.Regulates blood sugar levels

[Applications]

It’s widely used in health tonic, health pharmacy, hairdressing and cosmetic area, and mainly was applied in capsules, troche and oral liquids etc.

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Mechanisms underlying the anti-tumoral effect of Allium roseum L. extract on Chronic Myeloid Leukemia K562 cells

Communication de Soumaya Souid, doctorante à l”IPT, Colloque Jeunes Chercheurs de l’IPT (8-9 décembre 2016)

Background and objectives: Among various strategies that have been explored to overcome tumor drug
resistance, the combination of current chemotherapy with plant extracts as chemosensitizers has emerged
as a promising one. In the present study, we investigated for the first time the anti-cancer activity of Allium
roseum L. extract, a wild edible species in North Africa and its mechanisms against the well-characterized
human Chronic Myelogenous Leukemia (CML) K562 cells in vitro.
Methodology: K562 cells were treated with dehydrated aqueous (DAE) and fresh extracts in a time- and
dose-dependent manner. Cell viability and cytotoxicity were evaluated by MTT and LDH assays. Cell cycle
analysis and the apoptosis levels were assessed by flow cytometry. Using Western blot and Elisa assays, we
elicited key signaling pathways and effectors proteins targeted by DAE.
Results: DAE exhibited the highest antiproliferative activity on K562 cells even compared with the
chemotherapeutic drug Imatinib Mesylate, a tyrosine kinase inhibitor that targets the fusion oncoprotein
BCR-ABL responsible for this disease. DAE disturbed the cell cycle progression and induced the apoptosis
of K562 cells. Chemical analysis of DAE showed a diversity of organosulfur compounds RCSO and high
amount of allicin, suggesting that such molecule may be behind the anti-cancer effect of Allium roseum
extract. Similarly to Imatinib Mesylate, DAE inhibitory effect was associated with the dephosphorylation
of BCR-ABL kinase and interfered with the major prosurvival pathways, ERK1/2 and Akt. Furthermore, we
found that DAE-induced inactivation of Akt kinase led to the activation of its target FOXO3 transcription
factor, enhancing the expression of FOXO3-regulated pro-apoptotic effectors, Bim and Bax, and cell cycle
inhibitor p27. Finally, we found that DAE-treated K562 cells presented a reduced secretion of the proangiogenic
effector, Vascular Endothelial Growth Factor ( VEGF), compared to the non-treated cells.
Conclusion: Our data suggest that Allium roseum L. extract has great potential as a non-toxic cheap and
effective alternative to conventional chemotherapy that presents a dual inhibitory effect on both cancer
cell viability, through FOXO3 activation, and its angiogenic promoting regulator VEGF.