[Latin Name] Camellia sinensis

[Plant Source] China

[Specifications]

Total tea polyphenols 40%-98%

Total catechins 20%-90%

EGCG 8%-60%

[Appearance] Yellow brown powder

[Plant Part Used] Green tea leaf

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Package] Packed in paper-drums and two plastic-bags inside.

[What is green tea extract]

Green tea is the second largest beverage demanded by consumers worldwide. Used in China and India for its medicinal effects. There are several compounds extracted from green tea including catechins which contain an enormous amount of hydroxyphenols that are easily oxidized, congregated and contracted, which explains its good anti-oxidation effect. Its anti-oxidation effect is 25-100 times as strong as those of vitamin C and E.

It is widely used in medicines, agriculture, and chemical and food industries. This extract prevents cardio-vascular disease, lowers the risk of cancer, and decreases blood sugar and blood pressure, as well as viruses. In the food industry, the anti-oxidation agent used for preserving food and cooking oils.

[Function]

1. Green tea extract can reduce blood pressure, blood sugar, blood lipids.

2. Green tea extract has the function of removing radicals and anti-aging.

3. Green tea extract can enhance the immune function and prevention of colds.

4. Green tea extract will anti-radiation,anti-cancer, inhibiting the increasing of cancer cell.

5. Green tea extract used to anti-bacterium, with the function of sterilization and deodorization.

[Application]

1.Applied in cosmetics field, Green tea extract owns the effect of anti-wrinkle and anti-Aging.

2.Applied in food field, Green tea extract is used as natural antioxidant, antistaling agent, and anti-fading agents.

3.Applied in pharmaceutical field, Green tea extract is used to prevent and cure cardiovascular disease, diabetes.

Titre du document / Document title
Cytotoxic activity of Justicia spicigera is inhibited by bcl-2 proto-oncogene and induces apoptosis in a cell cycle dependent fashion
Auteur(s) / Author(s)
CACERES-CORTES J. R. (1) ; CANTU-GARZA F. A. (2) ; MENDOZA-MATA M. T. (3) ; CHAVEZ-GONZALEZ M. A. (1) ; RAMOS-MANDUJANO G. (1) ; ZAMBRANO-RAMIREZ I. R. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Research Unit of Cell Differentiation and Cancer, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, MEXIQUE
(2) Chemistry Engineering Department, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, ESPAGNE
(3) Pharmacology Department, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, ESPAGNE

Résumé / Abstract
Identification of organic compounds from plants is of clinical significance because of the effect that they might have in patients with haematopoietic disorders. We studied the effect of the plant extract Justicia spicigera (Acanthaceae) in different haematopoietic cells: human leukaemic cell lines, umbilical cord blood cells, and mouse bone marrow cells. By examining colony formation and performing the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay it was shown that the plant extract of Justicia spicigera contains cytotoxic factors for leukaemic cells and has no proliferative activity on normal haematopoietic progenitor cells. Our results show that this plant extract induces apoptosis in the human leukaemia cell line TF-1, but not in the bcl-2 transfectant cell line TB-1. Similar results were obtained using a haemopoietic cell line 32D and 32DBcl2. The cultures of umbilical cord blood cells and mouse bone marrow that contain granulocyte-macrophage colony-stimulating factor (GM-CSF) do not proliferate or become terminally differentiated in the presence of the infusion of Justicia spicigera. GM-CSF that acts by abrogating programmed cell death is not sufficient to inhibit the apoptotic stimulus in TF-1 and 32D cells. Moreover mouse fibroblasts (3T3) and two cervical carcinoma cell lines CALO and INBL, undergo apoptosis in the presence of different concentrations of an infusion from the plant. Our data show that there is a strong correlation between the cytotoxic effect and cell proliferation. Together, these results indicate that the plant infusion of Justicia spicigera does not contain any haematopoietic activity, induces apoptosis inhibited by bcl-2 and is linked to cell proliferation.
Revue / Journal Title
PTR. Phytotherapy research ISSN 0951-418X
Source / Source
2001, vol. 15, no8, pp. 691-697 (24 ref.)
Langue / Language
Anglais

Editeur / Publisher
Wiley, Chichester, ROYAUME-UNI (1987) (Revue)

Mots-clés anglais / English Keywords
America ; Central America ; Spermatophyta ; Angiospermae ; Dicotyledones ; Acanthaceae ; Mexico ; Folk medicine ; Pharmacognosy ; Animal ; Human ; Apoptosis ; In vitro ; Cell proliferation ; Antineoplastic agent ; Tumor cell ; Biological activity ; Cytotoxicity ; Plant origin ; Medicinal plant ;