[Latin Name] Valerian Officinalis I.

[Specification] Velerenic acid 0.8% HPLC

[Appearance] Brown powder

Plant Part Used: Root

[Particle size] 80Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is Valerian?]

Valerian root (valeriana officinalis) is derived from a plant native to Europe and Asia. The root of this plant has been used for thousands of years as a remedy for various ailments including sleep problems, digestive problems, and disorders of the nervous system, headaches, and arthritis. It is believed that valerian root has an impact on the availability of the neurotransmitter GABA in the brain.

[Function]

1. Beneficial for insomnia
2. FOR ANXIETY
3. AS A SEDATIVE
4. FOR OBSESSIVE COMPULSIVE DISORDER (OCD)
5. FOR DIGESTIVE PROBLEMS
6. FOR MIGRAINE FEADACHES
7. FOR HYPERACTIVITY AND FOCUS IN CHILDREN

UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 15. Introduction to Chemical Biology — Glycobiology & Polyketides — Part 1
View the complete course: https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.

License: Creative Commons BY-NC-SA
Terms of Use: https://ocw.uci.edu/info.
More courses at https://ocw.uci.edu

Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Introduction to Chemical Biology (Chem 128) is part of OpenChem: https://ocw.uci.edu/collections/open_chemistry.html
This video is part of a 18-lecture undergraduate-level course titled “Introduction to Chemical Biology” taught at UC Irvine by Professor Gregory Weiss.

Recorded March 5, 2013.

Index of Topics:
0:00:19 Carbohydrates
0:03:15 Glycosylated Proteins
0:07:25 Extending Oligosaccharides one Monomer at a Time
0:08:26 More Knee Join Oligosacchardies
0:10:25 Snot and Mucus: Anionic Polysaccharides
0:13:21 N-Linked Glycosides: Added as Complex Oligosaccharides
0:22:56 What is the Function of Glycosylation?
0:25:37 Cell Culture Production of Proteins
0:27:54 Glucoronidation Used to Designate Small Molecules for Excretion
0:29:49 Glucose Homeostasis
0:31:39 Non-Enzymatic Glycosylation
0:35:29 Sweetners: Tase Good for the Calories
0:41:00 Terpenes and Polyketides
0:45:09 Nature Prefers Thioesters for the Claisen
0:48:06 Rapid Exchange of Thioesters
0:49:28 Fatty Acid Synthesis by Polyketide

Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (https://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

Appetite Control | 3 Ways to Boost Weight Loss- Thomas DeLauer… Consulting, Business & Health – https://www.ThomasDeLauer.com
5-HTTP:
- 5-hydroxytryptophan (5-HTP) is a chemical that the body makes from tryptophan (an essential amino acid that you get from food).

5-HTP and Appetite

- Serotonin is a nervous system messenger, also called a neurotransmitter, with many functions in the body. One of those functions is that it can help to reduce appetite.

- In the body, 5–HTP crosses the blood–brain barrier and increases central nervous system (CNS) production of serotonin.

- Once the serotonin is produced it reduces or stops the hunger pangs. Two types of serotonin receptors (called 5–HT1B and 5–HT2C) have been specifically recognized as promoting serotonin–induced satiety. (1)

Coffee:
Chlorogenic Acid (CGA)

- Chlorogenic acid is a polyphenol antioxidant found in coffee.

- This antioxidant reduces blood glucose and insulin levels after a meal

- By slowing the release of glucose and keeping insulin levels low, you create a more favorable metabolic environment for releasing fatty acids.

Case Studies:
- In one study, it was found that CGA acts to suppress body weight gain and visceral fat accumulation in mice.

- Reported that CGA is possibly effective against weight gain and fat accumulation by inhibition of fat absorption and activation of fat metabolism in the liver

- Oral administration of CGA (30 and 60 mg/kg/day) for 14 days dramatically reduced the level of hepatic TG in mice

- Another study investigated the effect of CGA on altering body fat in high-fat diet (37% calories from fat) induced obese mice

- Found that CGA significantly lowered body weight, visceral fat mass and plasma leptin, and insulin levels compared to the high-fat control group

- Also lowered lowered triglyceride and cholesterol concentrations.

- Chlorogenic acid significantly inhibited fatty acid synthase, while they increased fatty acid beta-oxidation

- Results suggested that CGA can improve body weight, lipid metabolism, and obesity-related hormones levels (5)

Omega 3’s:
- Omega-3 fatty acids may suppress appetite because of their effect on leptin levels.

- Leptin is a hormone that affects appetite. When omega-3 fatty acid consumption is increased, leptin decreases, found a 2002 study published by the American Journal of Physiology

- Omega-3 fatty acids are considered essential fatty acids because your body can’t make them. You have to get them from food or supplements.

References:
1) 5-Hydroxytryptophan (5-HTP) | University of Maryland Medical Center. (n.d.). Retrieved from https://umm.edu/health/medical/altmed/supplement/5hydroxytryptophan-5htp

2) 5-HTP: A Highly Effective Appetite Suppressant | Weight Loss | Articles | Magazine. (n.d.). Retrieved from https://www.totalhealthmagazine.com/Weight-Loss/5-HTP-A-Highly-Effective-Appetite-Suppressant.html

3) The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. – PubMed – NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17882140

4) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea | Regulatory, Integrative and Comparative Physiology. (n.d.). Retrieved from https://ajpregu.physiology.org/content/292/1/R77

5) Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review. (n.d.). Retrieved from https://www.hindawi.com/journals/ecam/2013/801457/

6) Greasing the Wheels of Managing Overweight and Obesity with Omega-3 Fatty Acids. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210336/

7) New Study Shows Omega-3s Reduce Appetite – NaturalNews.com. (n.d.). Retrieved from https://www.naturalnews.com/024736_omega-3_omega-3s_research.html

8) Omega-3 fatty acids | University of Maryland Medical Center. (n.d.). Retrieved from https://umm.edu/health/medical/altmed/supplement/omega3-fatty-acids