[Latin Name] Coffea arabica L.

[Plant Source] from China

[Specifications] chlorogenic acid 10%-70%

[Appearance] Yellow brown fine powder

Plant Part Used:Bean

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[Brief Introduction]

Green Coffee Bean Extract is sourced from Europe and is standardized to more than 99% Chlorogenic Acid. Chlorogenic Acid is the compound present in coffee. Which has been long known as for its beneficial properties. This active ingredient akes Green Coffee Bean an excellent agent to absorb free oxygen radicals; as well as helping to avert hydroxyl radicals, both which contribute to degradation of cells in the body.Green Coffee Beans have strong polyphenols which act to help reduce free oxygen radicals in the body, but it is standardized to more than 99% Cholorgenic Acid, a dietary polyphenol that helps to regulate metabolism.Test results showed Green Coffee Bean had more than double the rate of oxygen radical absorbance capability when compared to green tea and grape seed extracts

[Main Functions]

1.Chlorogenic acid, long known as an antioxidant with potential anti-cancer activity, also slows the release of glucose into bloodstream after a meal.

2.lower one’sblood sugar level, suppress the appetite, lower blood pressure, and reduce levels of visceral fat.

3.Useful in fighting the free radicals in our bodies that can damage our cells and contribute to conditions such as cardiovascular disease. Test results

showed Green Coffee Bean had more than double the rate of oxygen radical absorbance capability when compared to green tea and grape seed extracts.

4.Act as an effective painkiller especially for migraine medications;

5.Reduce the risk of diabetes.

Video abstract of Original Research paper “Ulva lactuca polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation” published in the open access journal Breast Cancer – Targets and Therapy by Abd-Ellatef et al.

Background: Recently, several research studies have been focused on the isolation and function of the polysaccharides derived from different algal species, which revealed multiple biological activities such as antioxidant and antitumor activities. This study assesses the possible breast cancer chemopreventive properties of common seaweeds, sea lettuce, Ulva lactuca (ulvan) polysaccharides using in vitro bioassays on human breast cancer cell line (MCF-7) and an in vivo animal model of breast carcinogenesis.
Methods: Cytotoxic effect of ulvan polysaccharides on MCF-7 was tested in vitro. For an in vivo investigation, a single dose of 25 mg/kg body weight 7,12-dimethylbenz[a]anthracene (DMBA) and ulvan polysaccharides (50 mg/kg body weight every other day) for 10 weeks were administered orally to the Wistar rats.
Results: Deleterious histopathological alterations in breast tissues including papillary cyst adenoma and hyperplasia of ductal epithelial lining with intraluminal necrotic materials and calcifications were observed in the DMBA-administered group. These lesions were prevented in the DMBA-administered group treated with ulvan polysaccharides. The immunohistochemical sections depicted that the treatment of DMBA-administered rats with ulvan polysaccharides markedly increased the lowered pro-apoptotic protein, p53, and decreased the elevated anti-apoptotic
marker, bcl2, expression in the breast tissue. The elevated lipid peroxidation and the suppressed antioxidant enzyme activities in DMBA-administered control were significantly prevented by
the treatment with ulvan polysaccharides. The elevated levels of inflammatory cytokines tumor necrosis factor-α and nitric oxide were significantly ameliorated in DMBA-administered rats treated with ulvan polysaccharides as compared to DMBA-administered control.
Conclusion: In conclusion, ulvan polysaccharides at the level of initiation and promotion might have potential chemopreventive effects against breast carcinogenesis. These preventive effects
may be mediated through the augmentation of apoptosis, suppression of oxidative stress and inflammation, and enhancement of antioxidant defense system.

Read the Original Research paper here https://doi.org/10.2147/BCTT.S125165

UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 14. Introduction to Chemical Biology — Glycobiology
View the complete course: https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.

License: Creative Commons BY-NC-SA
Terms of Use: https://ocw.uci.edu/info.
More courses at https://ocw.uci.edu

Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Introduction to Chemical Biology (Chem 128) is part of OpenChem: https://ocw.uci.edu/collections/open_chemistry.html
This video is part of a 18-lecture undergraduate-level course titled “Introduction to Chemical Biology” taught at UC Irvine by Professor Gregory Weiss.

Recorded February 22. 2013.

Index of Topics:
0:02:04 Enzyme Functions
0:06:10 Serine Based Proteases
0:10:44 Protein Based Inhibition of Proteases
0:13:10 Covalent or Mechanism-Based Protease Inhibitors
0:15:02 Inhibition of Serine Esterases
0:17:07 Enzymes Use Co-Factors (Vitamins)
0:21:31 The Origins of Stereospecificity in Alcohol Dehydrogenase
0:24:09 Pyridozal Phosphate (Vitamin 86)
0:27:29 PLP – Catalyzed Transamination
0:29:29 Protein Engineering
0:36:16 Most Mutations Make the Protein Less Functional
0:38:17 Carbohydrates
0:44:30 Hemiacetal Reactivity and Formation
0:46:33 Glucopyranose is the Most Noteable Ring Configuration
0:47:51 Oligosaccharides of the TB Coat
0:51:29 Oxocarbenium Ions as a Key Intermediate in Hydrolysis of Glycosidic Bonds
0:53:19 Mechanisms of Enzymatic Hydrolysis
0:54:58 Commonalitites in Glycosylhydrolase Mechanisms
0:56:03 Neuraminidase: Key Enzyme in Influenza Release from Surface to Cell
1:01:06 Oligosaccharides
1:04:22 Polysaccharides
1:08:04 Hyaluronan: Oligosaccharides in Joints
1:09:57 Glycosylated Proteins

Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), https://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (https://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).