[Latin Name] Epimedium sagittatnm Maxim

[Plant Source] Leaf

[Specification] Icariin 10% 20% 40% 50%

[Appearance] Light yellow fine powder

Plant Part Used: Leaf

[Particle size]80Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is Epimedium?]

Epimedium extract is a popular aphrodisiac supplement and herbal sexual performance enhancer.It has a long history of traditional use in China for the alleviation of erectile dysfunction and for improving libido and fertility.

Also known as Horny Goat Weed, this supplement supposedly got its name after a farmer noticed that his flock of goats were particularly aroused after eating flowers of a specific type. These Epimedium flowers contain icariin, which is a natural compound that increases blood flow to sexual organs and promotes sex drive. Icariin has been found to increase Nitric Oxide synthesis as well as inhibiting the activity of the PDE-5 enzyme

[Icariin in Epimedium Extract]

Epimedium extracts powder contain an active phytochemical called icariin.Icariin has been observed to exhibit a number of useful traits, including renoprotective (liver protecting) hepatoprotective (kidney protecting), cardioprotective (heart protecting) and neuroprotective (brain protecting) effects.

It is also an antioxidant and can cause vasodilation. It exhibits antimicrobial characteristics and is thought to act as an aphrodisiac.

Icariin is classified as a flavonol glycoside, which is a type of flavonoid. Specifically, icariin is the 8-prenyl derivation of kaempferol 3,7-O-diglucoside, a prevalent and important flavonoid.

[Function]

1. Combat mental and physical fatigue;

2. Induce vasodilation and improve circulation;

3. Lower blood pressure in hypertensive patients;

4. Improve symptoms of erectile dysfunction (ED) through its action as a PDE5  inhibitor;

5. Improve the use of free testosterone in the blood;

6. Increase libido;

7. Alleviate symptoms of depression and stimulate improved cognitive function;

8. Protect against neurological degeneration.

MAINTAIN/RESTORE YOUTH & HEALTH NATURALLY
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Everybody is talking about anti-aging products and the new Resveratrol breakthrough.
The muscadine grape is the only grape with the extra chromosome. How Resveratrol and red wine activate genes for a longer and healthier life. Dr. Joseph Maroon – The Longevity Factor You want to purchase the book?
-On Page 193 Dr Maroon writes this on Vivix: There is growing evidence that a combination of resveratrol and other potent polyphenols might provide improved health benefits due to the synergistic properties of different polyphenols from different plant sources. a direct selling nutrition company has recently released a product called Vivix, which is described as a cellular anti-aging tonic. It contains a multi-source polyphenol blend. In conversations with the company, they state that the blend includes 100 mg of 98 percent pure resveratrol from Polygonum cuspidatum long with a proprietary extract derived from the fresh pomace of muscadine grapes (Vitis rotundifolia) The company recommends 5ml per day of Vivix, which they state is equivalent to the amount of resveratrol found in 100 glasses of red pinot noir red wine. The muscadine polyphenols in this blended product along with the added resveratrol, European elderberry extract, and purple carrot extract will increase the total overall polyphenol content of this product. A month’s supply will cost a member $85.00. In Shaklee’s accompanying literature for Vivix, they state that the Vivix ingredients were shown in a laboratory study to be 10 times more powerful in slowing a key mechanism of aging than resveratrol alone.”

Also, on Page 70, the author expands on the value of the muscadine grapes and the advantages over European grapes. “Muscadine grapes are native to
North America, and may be the only fruit that originated in the United States and nowhere else. They grow almost exclusively in the southeastern United Sates.
They thrive under adverse conditions, perhaps due to their thicker and tougher skins compared to European grapes…. muscadines have an extra
chromosome (twenty instead of the nineteen other grapes have). These additional genes allow muscadine grapes to produce a unique phytochemical, ellagic acid.
The ellagive acid polyphenol compounds that are in muscadine grapes are vitually absent in other grapes. Ellagic acid is used by the muscadine grape skin to make tannin called ellagotannins, whichis used as an antimicrobial by the plant. Ellagic acid also has powerful antioxidant and anticancer properties…. the polyphenols in muscadine grape skins have been shown to have positive effects in heart disease, high cholesterol, diabetes, metabolic syndrome, and other inflammatory conditions. One of the more interesting effects of muscadine products appears to be their inhibition of AGE protein formation.”

Continuing, the author states:” Recently, a large nutrition, direct selling company, working with scientists from the University of Georgia, has created a product containing an extract made from muscadine pomace which is the remaining fruit solids after the water content is extracted.
Specificaly, they are working with muscadine grape growers in order to secure grapes with large amounts of protective polyphenols including ellagic acid and resveratrol. By selecting muscadine grapes and by using a whole grape extraction process, they have reported that their extract has a significantly higher concentration of healthy polyphenols than found in the skins themselves.”

The above are excerpts from the book “The Longevity Factor” The author Joseph Maroon, M.D. FA.C.S. studied medicine at Indiana University, and Oxford University. Dr Maroon is a world renowned neurosurgeon and former president of the Congress of Neurological surgeons, the larges society of its kind in North America. He is currently a professor and Heindl Scholor in Neuroscience at the University of Pittsburgh Medical Center. Interesting to note: he is a lifelong athlete, competed in more than fifty triathlons, and’ three Hawaiian Ironman Championship competitions.

The book is heralded as a groundbreaking examination of new scientific research that holds the secret to weight loss, increased strength, endurance, memory,and a healthier, longer life.

Video abstract of original research paper “In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs” published in the open access journal Clinical, Cosmetic and Investigational Dermatology by McCook et al.

Background: Inhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents. Sodium copper chlorophyllin complex is being used therapeutically as a component in anti-aging cosmeceuticals, and has been shown to have anti-hyaluronidase activity. In this study we evaluated various commercial lots of sodium copper chlorophyllin complex to identify the primary small molecule constituents, and to test various sodium copper chlorophyllin complexes and their small molecule analog compounds for hyaluronidase inhibitory activity in vitro. Ascorbate analogs were tested in combination with copper chlorophyllin complexes for potential additive or synergistic activity.
Materials and methods: For hyaluronidase activity assays, dilutions of test materials were evaluated for hydrolytic activity of hyaluronidase by precipitation of non-digested hyaluronate by measuring related turbidity at 595 nm. High-performance liquid chromatography and mass spectroscopy was used to analyze and identify the primary small molecule constituents in various old and new commercial lots of sodium copper chlorophyllin complex.
Results: The most active small molecule component of sodium copper chlorophyllin complex was disodium copper isochlorin e4, followed by oxidized disodium copper isochlorin e4. Sodium copper chlorophyllin complex and copper isochlorin e4 disodium salt had hyaluronidase inhibitory activity down to 10 μg/mL. The oxidized form of copper isochlorin e4 disodium salt had substantial hyaluronidase inhibitory activity at 100 μg/mL but not at 10 μg/mL. Ascorbate derivatives did not enhance the hyaluronidase inhibitory activity of sodium copper chlorophyllin. Copper isochlorin e4 analogs were always the dominant components of the small molecule content of the commercial lots tested; oxidized copper isochlorin e4 was found in increased concentrations in older compared to newer lots tested.
Conclusion: These results support the concept of using the hyaluronidase inhibitory activity of sodium copper chlorophyllin complex to increase the hyaluronic acid level of the dermal extracellular matrix for the improvement of the appearance of aging facial skin.

View the original paper here: https://www.dovepress.com/in-vitro-inhibition-of-hyaluronidase-by-sodium-copper-chlorophyllin-co-peer-reviewed-article-CCID