[Dzina lachilatini]Huperzia serratum

[Source] Huperziceae therere lonse laku China

[Maonekedwe]Wofiirira mpaka woyera

[Zopangira]Huperzine A

[Matchulidwe]Huperzine A 1% - 5%, HPLC

[Kusungunuka] Kusungunuka mu chloroform, methanol, ethanol, kusungunuka pang'ono m'madzi

[Kukula kwa kachigawo] 80 Mesh

[Kutaya pakuyanika] ≤5.0%

[Chitsulo Cholemera] ≤10PPM

[Zotsalira za mankhwala] EC396-2005, USP 34, EP 8.0, FDA

[Kusungirako] Sungani pamalo ozizira komanso owuma, khalani kutali ndi kuwala kwachindunji ndi kutentha.

[Alumali moyo] 24 Miyezi

[Phukusi] Odzaza ndi mapepala-ng'oma ndi matumba awiri apulasitiki mkati.

[Huperzine A ndi chiyani?

Huperzia ndi mtundu wa moss womwe umamera ku China. Zimagwirizana ndi mosses zamakalabu (banja la Lycopodiaceae) ndipo akatswiri ena amadzimadzi amadziwika kuti Lycopodium serratum. Moss yonse yokonzedwa idagwiritsidwa ntchito mwamwambo. Kukonzekera kwa zitsamba zamakono kumagwiritsa ntchito alkaloid yokhayokha yomwe imadziwika kuti huperzine A. Huperzine A ndi alkaloid yomwe imapezeka mu huperzia yomwe yanenedwa kuti imalepheretsa kuwonongeka kwa acetylcholine, chinthu chofunikira kwambiri chomwe chimafunika ndi dongosolo lamanjenje kuti lipereke chidziwitso kuchokera ku selo kupita ku selo. Kafukufuku wa zinyama wasonyeza kuti mphamvu ya huperzine A yosunga acetylcholine ingakhale yaikulu kuposa ya mankhwala ena olembedwa ndi dokotala. Kutayika kwa ntchito ya acetylcholine ndi gawo loyamba la zovuta zingapo za ubongo, kuphatikizapo matenda a Alzheimer's. Huperzine A itha kukhalanso ndi chitetezo paminyewa yaubongo, ndikuwonjezera kuthekera kwake kothandizira kuchepetsa zizindikiro za zovuta zina zaubongo.

[Ntchito] Yogwiritsidwa ntchito m'mankhwala osagwiritsidwa ntchito masiku onse, huperzine A yapezedwa kuti imakhala ngati cholinesterase inhibitor, mtundu wa mankhwala omwe amagwiritsidwa ntchito poletsa kusweka kwa acetylcholine (mankhwala ofunikira pophunzira ndi kukumbukira).

Osagwiritsidwa ntchito ngati chithandizo cha matenda a Alzheimer's, huperzine A imanenedwanso kuti imathandizira kuphunzira ndi kukumbukira komanso kuteteza ku kuchepa kwa chidziwitso chokhudzana ndi ukalamba.

Kuonjezera apo, huperzine A nthawi zina amagwiritsidwa ntchito kulimbikitsa mphamvu, kuonjezera tcheru, ndi kuthandizira kuchiza myasthenia gravis (matenda a autoimmune omwe amakhudza minofu).

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Moni anyamata, lero ndakonza kanema wokhudza kutulutsa kosavuta kwambiri ndiko kunena kuti wowuma kuchokera ku mbatata yophika ndi mayeso ake achibale ndi tincture wa ayodini wamalonda. Asanayambe mawu awiri okha za wowuma. ndi polima zachilengedwe zomwe zilipo mu mpunga, phala, mbatata ndipo ndi gwero la mphamvu kwa zamoyo.
Amapangidwa ndi ma polima awiri osiyana: amylose 20% ndi amilopecten 80%. Onsewa ndi maunyolo opangidwa ndi mayunitsi a alpha glucose. Apa titha kuwona chithunzi chosavuta cha molekyulu ya wowuma yomwe ndi yovuta kwambiri.
Tsopano tiyeni tiyambe. Njirayi ndi yophweka kotero kuti mwana akhoza kuchita popanda mavuto. Mwachidule kutenga zana magalamu mbatata ndi peel izo. Tsopano yosavuta kabati izo. Akamaliza ikani mu beaker ndi mamilimita mazana awiri a madzi otentha. Tsopano sakanizani kwa mphindi imodzi kapena ziwiri. Kenako sefa ndi fyuluta yophika ku chidebe china. Ndi gawo lokhalitsa ndilo kunena kuti mbatata yophikidwa mukhoza kubwereza ntchitoyo kangapo kuwonjezera madzi ndi kusakaniza, ndikusefa kachiwiri koma izi ndizosankha. Pambuyo pa mphindi 5-10 wowuma, wosasungunuka m'madzi umatuluka. Apa tikutha kuwona kutsika koyera, kowuma koyera. Kungosuntha gawo lamadzimadzi kupita ku beaker ina mudzadzipatula. Lolani kuti ziume kutentha kwapakati. Apa titha kuwona wowuma ndipo amawoneka oyera, okoma pang'ono koma pambuyo pa esiccation adzakhala cristalline.
Tsopano, kuyesa kuti ndi wowuma kwenikweni osati ufa wamatsenga, tigwiritsa ntchito tincture wa ayodini (kusakaniza kwa ethanol, madzi, potassium iodide ndi elemental ayodini). Kuti muyese ikani wowuma mu chubu choyesera ndi madzi ndikugwedezani. Mukatha kuwonjezera tincture wa ayodini kuti mutha kuchepetsa ndi madzi kapena ayi. Komabe, yankho lidzakhala lamtundu wakuda wabuluu. Zomwe zimachitika ndikuti ayodini a ayodini (I3- ) amaphatikizana kuti amilose ndipo amapangitsa kuti gululo litenge mtundu uwu.
Moni wanga, tiwonana pakuyesa kotsatira.