[Dzina lachilatini]Huperzia serratum

[Source] Huperziceae therere lonse laku China

[Maonekedwe]Wofiirira mpaka woyera

[Zopangira]Huperzine A

[Matchulidwe]Huperzine A 1% - 5%, HPLC

[Kusungunuka] Kusungunuka mu chloroform, methanol, ethanol, kusungunuka pang'ono m'madzi

[Kukula kwa kachigawo] 80 Mesh

[Kutaya pakuyanika] ≤5.0%

[Chitsulo Cholemera] ≤10PPM

[Zotsalira za mankhwala] EC396-2005, USP 34, EP 8.0, FDA

[Kusungirako] Sungani pamalo ozizira komanso owuma, khalani kutali ndi kuwala kwachindunji ndi kutentha.

[Moyo wa alumali] Miyezi 24

[Phukusi] Odzaza ndi mapepala-ng'oma ndi matumba awiri apulasitiki mkati.

[Huperzine A ndi chiyani]

Huperzia ndi mtundu wa moss womwe umamera ku China. Zimagwirizana ndi mosses zamakalabu (banja la Lycopodiaceae) ndipo akatswiri ena amadzimadzi amadziwika kuti Lycopodium serratum. Moss yonse yokonzedwa idagwiritsidwa ntchito mwachikhalidwe. Kukonzekera kwa zitsamba zamakono kumagwiritsa ntchito alkaloid yokhayokha yomwe imadziwika kuti huperzine A. Huperzine A ndi alkaloid yomwe imapezeka mu huperzia yomwe yanenedwa kuti imalepheretsa kuwonongeka kwa acetylcholine, chinthu chofunikira kwambiri chomwe chimafunika ndi dongosolo lamanjenje kuti lipereke chidziwitso kuchokera ku selo kupita ku selo. Kafukufuku wa zinyama wasonyeza kuti mphamvu ya huperzine A yosunga acetylcholine ingakhale yaikulu kuposa ya mankhwala ena olembedwa ndi dokotala. Kutayika kwa ntchito ya acetylcholine ndi gawo loyamba la zovuta zingapo za ubongo, kuphatikizapo matenda a Alzheimer's. Huperzine A itha kukhalanso ndi chitetezo paminyewa yaubongo, ndikuwonjezera kuthekera kwake kothandizira kuchepetsa zizindikiro za zovuta zina zaubongo.

[Ntchito] Yogwiritsidwa ntchito m'mankhwala osagwiritsidwa ntchito masiku onse, huperzine A yapezedwa kuti imakhala ngati cholinesterase inhibitor, mtundu wa mankhwala omwe amagwiritsidwa ntchito poletsa kusweka kwa acetylcholine (mankhwala ofunikira pophunzira ndi kukumbukira).

Osagwiritsidwa ntchito ngati chithandizo cha matenda a Alzheimer's, huperzine A imanenedwanso kuti imathandizira kuphunzira ndi kukumbukira komanso kuteteza ku kuchepa kwa chidziwitso chokhudzana ndi ukalamba.

Kuonjezera apo, huperzine A nthawi zina amagwiritsidwa ntchito kulimbikitsa mphamvu, kuonjezera tcheru, ndi kuthandizira kuchiza myasthenia gravis (matenda a autoimmune omwe amakhudza minofu).

Wodwala uyu adachitidwa opaleshoni ya microsurgical ya glioblastoma multiforme yokulirapo. Hemostasis yathunthu idakwaniritsidwa mu 332 sec pogwiritsa ntchito MPH. Palibe chowonjezera chapamwamba cha hemostat kapena coagulation yamagetsi chomwe chinagwiritsidwa ntchito potseka hemostasis. Kujambula kwa postoperative cranial CT kunawonetsa kuti palibe magazi
zovuta.

Izi zatengedwa kuchokera ku Safety and Efficacy of MicroporousPolysaccharide Hemospheres mu Neurosurgery, zolemba zomwe zingathe kuwerengedwa apa https://journals.lww.com/neurosurgery/Fulltext/2011/09007/Safety_and_Efficacy_of_Microporous_Polysaccharide.8.aspx. Idaperekedwa ndi wolemba wina Joachim Oertel, MD, wochokera ku Neurochirurgische Klinik ku Mainz, Germany.

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