[Igama lesiLatini] I-Vitis vinifera Linn

[Umthombo Wezitshalo] Imbewu yamagilebhisi evela eYurophu

[Izincazelo] 95%OPCs;45-90% polyphenols

[Ukubukeka] Impushana ensundu ebomvu

[Ingxenye Yezitshalo Esetshenzisiwe]: imbewu

[Usayizi wezinhlayiyana] 80 Mesh

[Ukulahlekelwa lapho omiswa] ≤5.0%

[Insimbi Esindayo] ≤10PPM

[Izinsalela zezibulala-zinambuzane] EC396-2005, USP 34, EP 8.0, FDA

[Isitoreji] Gcina endaweni epholile neyomile, gwema ukukhanya nokushisa okuqondile.

[Impilo yeshelufu] Izinyanga ezingama-24

[Iphakheji] Ipakishwe ngezigubhu zephepha kanye nezikhwama zepulasitiki ezimbili ngaphakathi.

[Isici esijwayelekile]

1. Umkhiqizo wethu uphumelele ukuhlolwa kwe-ID yi-ChromaDex, i-Alkemist Lab. nokunye

izikhungo zokuhlola ezigunyaziwe ezivela eceleni, njengokutholwa;

2. Izinsalela zezibulala-zinambuzane ziyahambelana (EC) No 396/2005 USP34, EP8.0, FDA kanye nezinye izindinganiso nemithethonqubo yekhemisiyopoeia yangaphandle;

3. Izinsimbi ezisindayo ngokuhambisana ngokuqinile nezilawuli ezijwayelekile ze-pharmacopoeia zangaphandle, njenge-USP34, EP8.0, FDA, njll.;

4. Inkampani yethu yamisa igatsha futhi ingenisa izinto zokusetshenziswa ngokuqondile ezivela eYurophu ngokulawula okuqinile kwezinsalela zensimbi enzima nezibulala-zinambuzane. I-Aslo iqinisekisa ukuthi okuqukethwe kwe-procyanidins embewini yamagilebhisi kungaphezu kuka-8.0%.

5. Ama-OPC angaphezu kuka-95%, i-polyphenol ngaphezu kuka-70%, umsebenzi ophezulu, ukumelana ne-oxidation kunamandla, i-ORAC ingaphezu kuka-11000.

[Umsebenzi]

Amagilebhisi (Vitis vinifera) amenyezelwe ngenani lawo lokwelapha kanye nokudla okunempilo izinkulungwane zeminyaka. AbaseGibhithe badla amagilebhisi isikhathi eside kakhulu emuva, futhi izazi zefilosofi eziningana zasendulo zamaGreki zakhuluma ngamandla okuphulukisa amagilebhisi - ngokuvamile ngendlela yewayini. Izinyanga zaseYurophu zenza amafutha okugcoba ngamagilebhisi ukwelapha izifo zesikhumba nezamehlo. Amaqabunga amagilebhisi ayesetshenziselwa ukumisa ukopha, ukuvuvukala, nobuhlungu, njengohlobo olulethwa ama-hemorrhoids. Amagilebhisi angakavuthwa ayesetshenziselwa ukwelapha umphimbo obuhlungu, futhi amagilebhisi omisiwe (amagilebhisi) ayesetshenziselwa ukuqunjelwa kanye nokoma. Amagilebhisi ayindingilizi, avuthiwe, anoshukela ayesetshenziselwa ukwelapha izinkinga eziningi zempilo ezihlanganisa umdlavuza, ikholera, ingxibongo, isicanucanu, izifo zamehlo, nezifo zesikhumba, izinso nesibindi.

Imbewu yamagilebhisi ekhishwe yizimboni ezivela embewini yamagilebhisi egcwele inqwaba yevithamini E, flavonoids, linoleic acid kanye nama-phenolic OPCs. Ithuba elijwayelekile lezohwebo lokukhipha izingxenye zembewu yamagilebhisi kube ngelamakhemikhali aziwa ngokuthi ama-polyphenols anomsebenzi wokulwa ne-antioxidant in vitro.

Isifinyezo sevidiyo sephepha Lokuqala Locwaningo "I-Ulva lactuca polysaccharides ivimbela i-Wistar rat breast carcinogenesis ngokukhuliswa kwe-apoptosis, ukuthuthukiswa kohlelo lokuvikela i-antioxidant, nokucindezelwa kokuvuvukala" eshicilelwe kumagazini ovulekile wokufinyelela we-Breast Cancer - Targets and Therapy ka-Abd-Ellatef et al. .

Isendlalelo: Muva nje, izifundo zocwaningo ezimbalwa bezigxile ekuhlukaniseni nasekusebenzeni kwama-polysaccharides atholakala ezinhlotsheni ze-algal ezihlukene, okuveze imisebenzi eminingi yebhayoloji efana ne-antioxidant kanye nemisebenzi elwa nesimila. Lolu cwaningo luhlola izici ezingase zibe khona zokuvimbela umdlavuza webele zokhula lwasolwandle oluvamile, ulethisi wasolwandle, i-Ulva lactuca (ulvan) polysaccharides kusetshenziswa i-in vitro bioassays kumugqa weseli lomdlavuza webele womuntu (MCF-7) kanye nemodeli yezilwane e-vivo ye-breast carcinogenesis.
Izindlela: Umphumela we-Cytotoxic we-ulvan polysaccharides ku-MCF-7 uhlolwe ku-vitro. Ukuze kwenziwe uphenyo lwe-vivo, umthamo owodwa we-25 mg/kg wesisindo somzimba 7,12-dimethylbenz[a]anthracene (DMBA) kanye ne-ulvan polysaccharides (50 mg/kg isisindo somzimba njalo ngemva kosuku) amasonto ayi-10 anikezwa ngomlomo Amagundane e-Wistar.
Imiphumela: Ukuguqulwa okudelelekile kwe-histopathological ezicutshini zamabele okuhlanganisa i-papillary cyst adenoma kanye ne-hyperplasia ye-ductal epithelial lining ene-intraluminal necrotic materials kanye nokubalwa kwabonwa eqenjini elilawulwa yi-DMBA. Lezi zilonda zavinjelwa eqenjini elilawulwa yi-DMBA eliphathwa nge-ulvan polysaccharides. Izigaba ze-immunohistochemical zibonise ukuthi ukwelashwa kwamagundane alawulwa yi-DMBA nge-ulvan polysaccharides kwandise ngokuphawulekayo amaprotheni e-pro-apoptotic ehlisiwe, i-p53, futhi kwehlisa i-anti-apoptotic ephakeme.
umaka, bcl2, ukubonakaliswa esicutshini sebele. Ukwenyuka kwe-lipid peroxidation kanye nemisebenzi ecindezelwe ye-antioxidant ye-enzyme ekulawuleni okulawulwa yi-DMBA kuvinjwe kakhulu
ukwelashwa nge-ulvan polysaccharides. Amazinga aphakanyisiwe we-cytokines tumor necrosis factor-α kanye ne-nitric oxide athuthukisiwe kakhulu kumagundane alawulwa yi-DMBA aphathwe nge-ulvan polysaccharides uma kuqhathaniswa nokulawula okulawulwa yi-DMBA.
Isiphetho: Ekuphetheni, ama-ulvan polysaccharides ezingeni lokuqala nokukhuthazwa angase abe nemiphumela engaba khona ye-chemopreventive ngokumelene ne-breast carcinogenesis. Le miphumela yokuvimbela
ingase ilamule ngokukhuliswa kwe-apoptosis, ukucindezelwa kokucindezeleka okwenziwe nge-oxidative nokuvuvukala, kanye nokuthuthukiswa kohlelo lokuzivikela lwe-antioxidant.

Funda iphepha lokuqala locwaningo lapha https://doi.org/10.2147/BCTT.S125165

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