[Igama lesiLatini]Huperzia serratum

[Umthombo] I-Huperziceae yonke imifino evela e-China

[Ukubukeka]Onsundu ukuya kokumhlophe

[Isithako]Huperzine A

[Ukucaciswa]I-Huperzine A 1% – 5%, HPLC

[Ukunyibilika] Incibilika ku-chloroform, i-methanol, i-ethanol, inyibilika kancane emanzini

[Usayizi wezinhlayiyana] 80 Mesh

[Ukulahlekelwa lapho omiswa] ≤5.0%

[Insimbi Esindayo] ≤10PPM

[Izinsalela zezibulala-zinambuzane] EC396-2005, USP 34, EP 8.0, FDA

[Isitoreji] Gcina endaweni epholile neyomile, gwema ukukhanya nokushisa okuqondile.

[Impilo yeshelufu] Izinyanga ezingama-24

[Iphakheji] Ipakishwe ngezigubhu zephepha kanye nezikhwama zepulasitiki ezimbili ngaphakathi.

[Iyini i-Huperzine A]

I-Huperzia uhlobo lobulembu obumila eShayina. Ihlobene ne-club mosses (umndeni we-Lycopodiaceae) futhi yaziwa kwezinye izazi zezitshalo ngokuthi i-Lycopodium serratum. I-moss yonke elungisiwe yayisetshenziswa ngokwesiko. Amalungiselelo amakhambi esimanje asebenzisa kuphela i-alkaloid engayodwa eyaziwa ngokuthi i-huperzine A. I-Huperzine A iyi-alkaloid etholakala ku-huperzia okuye kwabikwa ukuthi ivimbela ukuwohloka kwe-acetylcholine, into ebalulekile edingwa isimiso sezinzwa ukuze sidlulisele ulwazi kusuka kungqamuzana ukuya kungqamuzana. Ucwaningo lwezilwane luphakamise ukuthi ikhono le-huperzine A lokulondoloza i-acetylcholine lingase libe likhulu kuneleminye imithi kadokotela. Ukulahlekelwa ukusebenza kwe-acetylcholine kuyisici esiyinhloko sokuphazamiseka okuningana kokusebenza kobuchopho, okuhlanganisa nesifo i-Alzheimer's. I-Huperzine A ingase futhi ibe nomthelela ovikelayo ezicutshini zobuchopho, iqhubeke yandise amandla ayo etiyetha okusiza ukwehlisa izimpawu zokuphazamiseka okuthile kobuchopho.

[Umsebenzi] Isetshenziswa kwezinye izindlela zokwelapha, i-huperzine A itholakale isebenza njenge-cholinesterase inhibitor, uhlobo lomuthi olusetshenziselwa ukuvimbela ukuwohloka kwe-acetylcholine (ikhemikhali ebalulekile ekufundeni nasekukhumbuleni).

Ayisetshenziswa nje kuphela njengokwelapha isifo i-Alzheimer's, i-huperzine A kuthiwa ithuthukisa ukufunda nenkumbulo futhi ivikele ekuwohlokeni komqondo okuhlobene neminyaka.

Ngaphezu kwalokho, i-huperzine A ngezinye izikhathi isetshenziselwa ukuqinisa amandla, ukwandisa ukuphaphama, nokusiza ekwelapheni i-myasthenia gravis (isifo esizimele esithinta imisipha).

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Ngibonga kakhulu ngokuba nawe kulolu hambo oluhlanya olubizwa ngokuthi impilo.

Ngibonga kakhulu emndenini wami omncane omuhle, ithimba lami elimangalisayo nababheki bami. Ngikuthumela lonke uthando lwami.

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IHydr8 Night iyisikhutha esinothile, esifaka amanzi ngamandla, nesithambisa ebusukuI-Resveratrolimpilo ende yeseli kanye ne-Beta evuselelayoGlucan.

Ifanele zonke izinhlobo zesikhumba. Ifaneleka kahle ukusetshenziswa ne-Medik8 Retinol 3 TR.

I-Medik8 isebenzisa amandla ochwephesheI-Resveratrolisuselwa ku-Japanese Giant Knotweed egxile kakhulu kunemithombo yesikhumba samagilebhisi.I-Resveratrol iyisigaba esisha sesithako, esibizwa ngokuthi iSilent Information Regulator, esikhuthaza ukuphila isikhathi eside kwamaseli nokusiza ukuthuthukisa ukubukeka kwesikhumba esikhathele ngobusuku obubodwa. I-Beta-Glucan , ngokuvamile etholakala kumakhowe aseJapane, iyisithako sesibili esinamandla kakhulu ku-Hydr8 Night. I-Beta-Glucanisiza ukusekela izindlela zemvelo zokubuyisela isikhumba futhi ilungele ukuvuselela ukuthungwa kwesikhumba ebusuku.

Kanye nokukhishwa kwezitshalo okupholisayo, okuhlanganisa i-Valerian ne-Passionflower, i-Hydr8 Night iyincazelo entsha ngemuva 'kobuthongo bobuhle'.

I-Resveratrol i-phytoalexin, uhlobo lwesibulala-magciwane olukhiqizwa ngokwemvelo izitshalo ezihlaselwa amagciwane afana namagciwane noma isikhunta, kanye nokuchayeka kwe-UV noma ukulimala ngokomzimba. Ine-antioxidant enamandla, eqeda ukuvuvukala kanye ne-anti-carcinogenic futhi idume kakhulu ngamandla ayo okwandisa impilo ende yamaselula. Isisekelo salezi zimangalo sakhelwe phezu kokutholwa kukaDavid Sinclair, PhD, eHarvard University, owasungula ukuthi i-resveratrol inomthelela emsebenzini womndeni we-sirtuin gene, owaziwa nangokuthi "izakhi zofuzo zokuphila isikhathi eside" - iqembu lezakhi zofuzo eziyi-7. okuhambisana nenqubo yokuguga. I-Sirtuin ivame ukubizwa ngokuthi 'umvikeli wamaseli' njengoba isiza amaseli ngokuzilungisa wona uma esesondele ekubhujisweni. Lapho ingqamuzana lingabaza phakathi komzabalazo noma ukuzinikela, u-sirtuin uyangena futhi alinxenxe ukuba liqhubeke nokuzilungisa. Ngaphandle kwe-sirtuin, iseli belizofa futhi njengoba amaseli efa, iminyaka eyodwa.

I-Resveratrol ngokwemvelo kwenzeka ngezindlela ezimbili ze-isomer - i-cis ne-trans. Kulokhu okubili, yi-trans isomer ekhonjiswe ezifundweni eziningi ukuthi iyindlela esebenzayo kakhulu nenenzuzo ye-resveratrol. I-Medik8 isebenzisa kuphela uhlobo lwe-chirally olulungile lwe-resveratrol etholakala ku-Japanese Knotweed - isitshalo esiqinile, esine-herbaceous perennial esivame ukubhekwa njengomthombo omningi nothembekile we-resveratrol.