[Igama lesiLatini]Huperzia serratum

[Umthombo] I-Huperziceae yonke imifino evela e-China

[Ukubukeka]Onsundu ukuya kokumhlophe

[Isithako]Huperzine A

[Ukucaciswa]I-Huperzine A 1% – 5%, HPLC

[Ukunyibilika] Incibilika ku-chloroform, i-methanol, i-ethanol, inyibilika kancane emanzini

[Usayizi wezinhlayiyana] 80 Mesh

[Ukulahlekelwa lapho omiswa] ≤5.0%

[Insimbi Esindayo] ≤10PPM

[Izinsalela zezibulala-zinambuzane] EC396-2005, USP 34, EP 8.0, FDA

[Isitoreji] Gcina endaweni epholile neyomile, gwema ukukhanya nokushisa okuqondile.

[Impilo yeshelufu] Izinyanga ezingama-24

[Iphakheji] Ipakishwe ngezigubhu zephepha kanye nezikhwama zepulasitiki ezimbili ngaphakathi.

[Iyini i-Huperzine A]

I-Huperzia uhlobo lobulembu obumila eShayina. Ihlobene ne-club mosses (umndeni we-Lycopodiaceae) futhi yaziwa kwezinye izazi zezitshalo ngokuthi i-Lycopodium serratum. I-moss yonke elungisiwe yayisetshenziswa ngokwesiko. Amalungiselelo amakhambi esimanje asebenzisa kuphela i-alkaloid engayodwa eyaziwa ngokuthi i-huperzine A. I-Huperzine A iyi-alkaloid etholakala ku-huperzia okuye kwabikwa ukuthi ivimbela ukuwohloka kwe-acetylcholine, into ebalulekile edingwa isimiso sezinzwa ukuze sidlulisele ulwazi kusuka kungqamuzana ukuya kungqamuzana. Ucwaningo lwezilwane luphakamise ukuthi ikhono le-huperzine A lokulondoloza i-acetylcholine lingase libe likhulu kuneleminye imithi kadokotela. Ukulahlekelwa ukusebenza kwe-acetylcholine kuyisici esiyinhloko sokuphazamiseka okuningana kokusebenza kobuchopho, okuhlanganisa nesifo i-Alzheimer's. I-Huperzine A ingase futhi ibe nomthelela ovikelayo ezicutshini zobuchopho, iqhubeke yandise amandla ayo etiyetha okusiza ukwehlisa izimpawu zokuphazamiseka okuthile kobuchopho.

[Umsebenzi] Isetshenziswa kwezinye izindlela zokwelapha, i-huperzine A itholakale isebenza njenge-cholinesterase inhibitor, uhlobo lomuthi olusetshenziselwa ukuvimbela ukuwohloka kwe-acetylcholine (ikhemikhali ebalulekile ekufundeni nasekukhumbuleni).

Ayisetshenziswa nje kuphela njengokwelapha isifo i-Alzheimer's, i-huperzine A kuthiwa ithuthukisa ukufunda nenkumbulo futhi ivikele ekuwohlokeni komqondo okuhlobene neminyaka.

Ngaphezu kwalokho, i-huperzine A ngezinye izikhathi isetshenziselwa ukuqinisa amandla, ukwandisa ukuphaphama, nokusiza ekwelapheni i-myasthenia gravis (isifo esizimele esithinta imisipha).

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Sawubona bafo, namuhla ngilungiselele ividiyo mayelana nesizinda esilula kakhulu okusho ukuthi isitashi kusuka kumazambane okupheka kanye nokuhlolwa kwawo okuhlobene ne-tincture yokuhweba ye-iodine. Ngaphambi kokuqala amagama amabili nje mayelana nesitashi. iyi-polymer yemvelo ekhona elayisi, i-ceral, amazambane futhi iwumthombo wamandla ezidalwa eziphilayo.
Yakhiwe ngama-polymer amabili ahlukene: i-amylose 20% ne-amilopecten 80%. Womabili amaketanga akhiwe amayunithi e-alpha glucose. Lapha singabona isithombe esenziwe lula se-molecule yesitashi esiyinkimbinkimbi kakhulu.
Manje ake siqale. Inqubo ilula kangangokuthi nengane ingakwenza lokho ngaphandle kwezinkinga. Mane uthathe amazambane ayikhulu amagremu bese uwacwecwa. Manje yigaye kalula. Uma usuqedile uyibeke ebhekhani elinamanzi ashisayo angamamilimitha angamakhulu amabili. Manje hlanganisa cishe imizuzu eyodwa-emibili. Bese uhlunga ngesihlungi sokupheka kwesinye isitsha. Ngengxenye ehlala njalo okusho ukuthi amazambane agayiwe ungaphinda ukuhlinzwa izikhathi eziningana wengeza amanzi nokuxuba, futhi ukuhlunga futhi kodwa lokhu ukuzikhethela. Ngemuva kwemizuzu engu-5-10 isitashi, esingancibiliki emanzini sizophuma. Lapha singabona imvula emhlophe, isitashi esimsulwa. Ngokumane uhambise isigaba se-liquid kwelinye ibhika uzohlukanisa umkhiqizo. Ivumele yome ekamelweni lokushisa. Lapha singabona isitashi futhi sibonakala simhlophe, sithe ukukhilimu kancane kodwa ngemva kwe-esiccation sizoba cristalline.
Manje, ukuhlola ukuthi isitashi ngempela hhayi impushana yomlingo, sizosebenzisa i-tincture ye-iodine (ingxube ye-ethanol, amanzi, i-potassium iodide kanye ne-elemental iodine). Ukuyihlola faka isitashi eshubhuni yokuhlola enamanzi athile bese unyakaza. Ngemuva kokufaka i-tincture ye-iodine ongayinciphisa ngamanzi noma cha. Nokho, ikhambi lizoba nombala oluhlaza okwesibhakabhaka omnyama. Okwenzekayo ukuthi ama-ion e-iodine (I3- ) ahlangana ukuze amilose futhi enze inhlanganisela ithathe lo mbala.
Ngiyabingelela, sobonana esivivinyweni esilandelayo.